DVL3 Antibody - #DF4455

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Product: DVL3 Antibody
Catalog: DF4455
Description: Rabbit polyclonal antibody to DVL3
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Monkey
Prediction: Pig, Bovine, Horse, Sheep, Dog, Xenopus
Mol.Wt.: 78 KD; 78kD(Calculated).
Uniprot: Q92997
RRID: AB_2836810

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Monkey
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Dog(100%), Xenopus(100%)
Clonality:
Polyclonal
Specificity:
DVL3 Antibody detects endogenous levels of total DVL3.
RRID:
AB_2836810
Cite Format: Affinity Biosciences Cat# DF4455, RRID:AB_2836810.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Dishevelled 3 (homologous to Drosophila dsh); Dishevelled 3; Dishevelled 3, dsh homolog (Drosophila); Dishevelled, dsh homolog 3 (Drosophila); Dishevelled-3; DSH homolog 3; dvl3; DVL3_HUMAN; KIAA0208; OTTHUMP00000210777; OTTHUMP00000210778; Segment polarity protein dishevelled homolog DVL 3; Segment polarity protein dishevelled homolog DVL-3;

Immunogens

Immunogen:
Uniprot:

Q92997(DVL3_HUMAN) >>Visit HPA database.

Gene(ID):
DVL3(1857)
Sequence:
MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPDPAPFCADNPSELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHATRLNGTAKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLASSLRSHHTHPSYGPPGVPPLYGPPMLMMPPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q92997 As Substrate

Site PTM Type Enzyme
Ubiquitination
T15 Phosphorylation
R27 Methylation
K34 Ubiquitination
S41 Phosphorylation
S48 Phosphorylation
S61 Phosphorylation
S116 Phosphorylation
S125 Phosphorylation
T133 Phosphorylation
T135 Phosphorylation
S137 Phosphorylation
S140 Phosphorylation
S175 Phosphorylation
S192 Phosphorylation
S197 Phosphorylation
S202 Phosphorylation
S203 Phosphorylation
S204 Phosphorylation
T205 Phosphorylation
S208 Phosphorylation
S209 Phosphorylation
S211 Phosphorylation
R212 Methylation
S232 Phosphorylation
S234 Phosphorylation
S237 Phosphorylation
S244 Phosphorylation
Y257 Phosphorylation
S268 Phosphorylation
R271 Methylation
S280 Phosphorylation
K283 Ubiquitination
S311 Phosphorylation
K325 Ubiquitination
S340 Phosphorylation
R342 Methylation
T346 Phosphorylation
S350 Phosphorylation
S421 Phosphorylation
K466 Ubiquitination
K473 Ubiquitination
S512 Phosphorylation
S516 Phosphorylation
S564 Phosphorylation
S566 Phosphorylation
S567 Phosphorylation
S570 Phosphorylation
S573 Phosphorylation
S575 Phosphorylation
S576 Phosphorylation
S578 Phosphorylation
S596 Phosphorylation
S598 Phosphorylation
S601 Phosphorylation
S603 Phosphorylation
S605 Phosphorylation
T608 Phosphorylation
T609 Phosphorylation
S611 Phosphorylation
S612 Phosphorylation
S622 Phosphorylation
S625 Phosphorylation
S633 Phosphorylation
S636 Phosphorylation
S639 Phosphorylation
S642 Phosphorylation
S643 Phosphorylation
S689 Phosphorylation
S697 Phosphorylation
R698 Methylation
S700 Phosphorylation

Research Backgrounds

Function:

Involved in the signal transduction pathway mediated by multiple Wnt genes.

PTMs:

Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains.

Phosphorylated by CSNK1D.

Arginine methylation may function as a switch in regulation of function in Wnt signaling.

Subcellular Location:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 (By similarity). Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD, CEP164 and DAB2. Interacts with DCDC2. Interacts with FOXK1 and FOXK2. Interacts with DAAM2 (By similarity).

Family&Domains:

Belongs to the DSH family.

Research Fields

· Cellular Processes > Cellular community - eukaryotes > Signaling pathways regulating pluripotency of stem cells.   (View pathway)

· Environmental Information Processing > Signal transduction > mTOR signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Wnt signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Notch signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Hippo signaling pathway.   (View pathway)

· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Basal cell carcinoma.   (View pathway)

· Human Diseases > Cancers: Specific types > Breast cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma.   (View pathway)

· Human Diseases > Cancers: Specific types > Gastric cancer.   (View pathway)

· Organismal Systems > Endocrine system > Melanogenesis.

Restrictive clause

 

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For Research Use Only.
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