ALDH3B1 Antibody - #DF3754

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Product: ALDH3B1 Antibody
Catalog: DF3754
Description: Rabbit polyclonal antibody to ALDH3B1
Application: WB IHC IF/ICC
Reactivity: Human
Prediction: Mouse, Pig, Bovine
Mol.Wt.: 52 KD; 52kD(Calculated).
Uniprot: P43353
RRID: AB_2836118

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Prediction:
Mouse(%), Pig(82%), Bovine(91%)
Clonality:
Polyclonal
Specificity:
ALDH3B1 Antibody detects endogenous levels of total ALDH3B1.
RRID:
AB_2836118
Cite Format: Affinity Biosciences Cat# DF3754, RRID:AB_2836118.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Aldehyde dehydrogenase 3B1; Aldehyde dehydrogenase 7; Aldehyde dehydrogenase family 3 member B1; ALDH4; ALDH7; FLJ26433;

Immunogens

Immunogen:
Uniprot:

P43353(AL3B1_HUMAN) >>Visit HPA database.

Gene(ID):
ALDH3B1(221)
Expression:
P43353 AL3B1_HUMAN:

Highest expression in kidney and lung.

Sequence:
MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSPGMEKLNALRYPPQSPRRLRMLLVAMEAQGCSCTLL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Bovine
91
Pig
82
Xenopus
44
Horse
0
Sheep
0
Dog
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P43353 As Substrate

Site PTM Type Enzyme
M1 Acetylation
K41 Ubiquitination
K89 Ubiquitination
K148 Ubiquitination
Y183 Phosphorylation
T187 Phosphorylation
S189 Phosphorylation
K194 Ubiquitination
K202 Ubiquitination
T205 Phosphorylation
T208 Phosphorylation
K214 Ubiquitination
K289 Ubiquitination
K360 Ubiquitination
S368 Phosphorylation
K375 Ubiquitination
K437 Ubiquitination
S464 Phosphorylation

Research Backgrounds

Function:

Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor. May have a protective role against the cytotoxicity induced by lipid peroxidation.

PTMs:

Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates.

Subcellular Location:

Cell membrane>Lipid-anchor.
Note: Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Highest expression in kidney and lung.

Family&Domains:

Belongs to the aldehyde dehydrogenase family.

Research Fields

· Human Diseases > Cancers: Overview > Chemical carcinogenesis.

· Metabolism > Carbohydrate metabolism > Glycolysis / Gluconeogenesis.

· Metabolism > Amino acid metabolism > Histidine metabolism.

· Metabolism > Amino acid metabolism > Tyrosine metabolism.

· Metabolism > Amino acid metabolism > Phenylalanine metabolism.

· Metabolism > Metabolism of other amino acids > beta-Alanine metabolism.

· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.

· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.

· Metabolism > Global and overview maps > Metabolic pathways.

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