IL-2R beta/CD122 Antibody - #AF6926
| Product: | IL-2R beta/CD122 Antibody |
| Catalog: | AF6926 |
| Description: | Rabbit polyclonal antibody to IL-2R beta/CD122 |
| Application: | ELISA(peptide) |
| Reactivity: | Human, Mouse, Rat |
| Mol.Wt.: | 61kD(Calculated). |
| Uniprot: | P14784 |
| RRID: | AB_2847716 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF6926, RRID:AB_2847716.
Fold/Unfold
CD122; CD122 antigen; High affinity IL 2 receptor beta subunit; High affinity IL 2 receptor subunit beta; High affinity IL-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; IL15RB; IL2 receptor; IL2RB; IL2RB_HUMAN; Interleukin 2 receptor beta; Interleukin-2 receptor subunit beta; P70 75; P70-75; P7075; p75;
Immunogens
A synthesized peptide derived from human IL-2R beta/CD122.
- P14784 IL2RB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAPALSWRLPLLILLLPLATSWASAAVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDTIPWLGHLLVGLSGAFGFIILVYLLINCRNTGPWLKKVLKCNTPDPSKFFSQLSSEHGGDVQKWLSSPFPSSSFSPGGLAPEISPLEVLERDKVTQLLLQQDKVPEPASLSSNHSLTSCFTNQGYFFFHLPDALEIEACQVYFTYDPYSEEDPDEGVAGAPTGSSPQPLQPLSGEDDAYCTFPSRDDLLLFSPSLLGGPSPPSTAPGGSGAGEERMPPSLQERVPRDWDPQPLGPPTPGVPDLVDFQPPPELVLREAGEEVPDAGPREGVSFPWSRPPGQGEFRALNARLPLNTDAYLSLQELQGQDPTHLV
PTMs - P14784 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S7 | Phosphorylation | Uniprot | |
| N43 | N-Glycosylation | Uniprot | |
| N71 | N-Glycosylation | Uniprot | |
| T105 | Phosphorylation | Uniprot | |
| N149 | N-Glycosylation | Uniprot | |
| T282 | Phosphorylation | Uniprot | |
| S293 | Phosphorylation | Uniprot | |
| Y364 | Phosphorylation | P23458 (JAK1) | Uniprot |
| Y381 | Phosphorylation | P06239 (LCK) | Uniprot |
| Y384 | Phosphorylation | P06239 (LCK) | Uniprot |
| Y387 | Phosphorylation | P06239 (LCK) | Uniprot |
| Y418 | Phosphorylation | P06239 (LCK) | Uniprot |
| S431 | Phosphorylation | Uniprot | |
| S458 | Phosphorylation | Uniprot | |
| T476 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | Uniprot |
| Y536 | Phosphorylation | P06239 (LCK) | Uniprot |
Research Backgrounds
Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
Cell membrane>Single-pass type I membrane protein.
Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation.
(Microbial infection) Interacts with HTLV-1 accessory protein p12I.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Belongs to the type I cytokine receptor family. Type 4 subfamily.
Research Fields
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
· Organismal Systems > Immune system > Th1 and Th2 cell differentiation. (View pathway)
· Organismal Systems > Immune system > Th17 cell differentiation. (View pathway)
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