PEN2 Antibody - #DF13538
| Product: | PEN2 Antibody |
| Catalog: | DF13538 |
| Description: | Rabbit polyclonal antibody to PEN2 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| Mol.Wt.: | 12kDa; 12kD(Calculated). |
| Uniprot: | Q9NZ42 |
| RRID: | AB_2846557 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF13538, RRID:AB_2846557.
Fold/Unfold
Gamma secretase subunit PEN 2; Gamma Secretase Subunit PEN2; Gamma-secretase subunit PEN-2; Hematopoietic stem/progenitor cells protein MDS033; MDS033; MSTP064; PEN 2; PEN2_HUMAN; Presenilin Enhancer 2; Presenilin enhancer 2 homolog; Presenilin enhancer protein 2; PSEN2; psenen;
Immunogens
Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
- Q9NZ42 PEN2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTP
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NZ42 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K11 | Ubiquitination | Uniprot |
Research Backgrounds
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity.
Endoplasmic reticulum membrane>Multi-pass membrane protein. Golgi apparatus>Golgi stack membrane>Multi-pass membrane protein. Cell membrane>Multi-pass membrane protein. Membrane>Multi-pass membrane protein.
Note: Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.
The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN.
Belongs to the PEN-2 family.
Research Fields
· Environmental Information Processing > Signal transduction > Notch signaling pathway. (View pathway)
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
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