Product: COQ7 Antibody
Catalog: DF12259
Description: Rabbit polyclonal antibody to COQ7
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 22 kDa; 24kD(Calculated).
Uniprot: Q99807
RRID: AB_2845064

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 100ul $280 In stock
 200ul $350 In stock

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Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Zebrafish(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
Clonality:
Polyclonal
Specificity:
COQ7 Antibody detects endogenous levels of total COQ7.
RRID:
AB_2845064
Cite Format: Affinity Biosciences Cat# DF12259, RRID:AB_2845064.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

5 demethoxyubiquinone hydroxylase mitochondrial; CAT5; CLK 1; CLK1; Coenzyme Q biosynthesis protein 7 homolog; Coenzyme Q7 homolog ubiquinone; Coenzyme Q7 hydroxylase; COQ10D8; coq7; COQ7 coenzyme Q 7 homolog ubiquinone; COQ7 protein; COQ7_HUMAN; DMQ hydroxylase; Placental protein KG 20; Timing protein clk-1 homolog; Ubiquinone biosynthesis monooxygenase COQ7; Ubiquinone biosynthesis protein COQ7 homolog;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
Q99807 COQ7_HUMAN:

Expressed dominantly in heart and skeletal muscle.

Sequence:
MSCAGAAAAPRLWRLRPGARRSLSAYGRRTSVRFRSSGMTLDNISRAAVDRIIRVDHAGEYGANRIYAGQMAVLGRTSVGPVIQKMWDQEKDHLKKFNELMVTFRVRPTVLMPLWNVLGFALGAGTALLGKEGAMACTVAVEESIAHHYNNQIRTLMEEDPEKYEELLQLIKKFRDEELEHHDIGLDHDAELAPAYAVLKSIIQAGCRVAIYLSERL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Zebrafish
100
Chicken
100
Rabbit
100
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q99807 As Substrate

Site PTM Type Enzyme
S22 Phosphorylation
Y26 Phosphorylation
R51 Methylation
K85 Ubiquitination
K95 Acetylation
K96 Acetylation
K173 Ubiquitination

Research Backgrounds

Function:

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.

Subcellular Location:

Mitochondrion inner membrane>Peripheral membrane protein>Matrix side.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed dominantly in heart and skeletal muscle.

Subunit Structure:

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9 (By similarity). Interacts with COQ8B and COQ6. Interacts with COQ9.

Family&Domains:

Belongs to the COQ7 family.

Research Fields

· Metabolism > Metabolism of cofactors and vitamins > Ubiquinone and other terpenoid-quinone biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

Restrictive clause

 

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For Research Use Only.
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