CREB3L4 Antibody - #DF9070
| Product: | CREB3L4 Antibody |
| Catalog: | DF9070 |
| Description: | Rabbit polyclonal antibody to CREB3L4 |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 43 kDa; 43kD(Calculated). |
| Uniprot: | Q8TEY5 |
| RRID: | AB_2842266 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF9070, RRID:AB_2842266.
Fold/Unfold
1700012K17Rik; AIbZIP; Androgen induced basic leucine zipper; Androgen induced basic leucine zipper protein; Androgen-induced basic leucine zipper protein; ATCE1; Attaching to CRE like 1; Attaching to CRE-like 1; cAMP responsive element binding protein 1; cAMP responsive element binding protein 3 like 4; cAMP responsive element binding protein 4; cAMP responsive element-binding protein 3 like protein 4; cAMP-responsive element-binding protein 3-like protein 4; cAMP-responsive element-binding protein 4; CR3L4_HUMAN; CREB 4; CREB-4; CREB3; CREB3L4; CREB4; Cyclic AMP responsive element binding protein 3 like protein 4; Cyclic AMP responsive element binding protein 4; Cyclic AMP-responsive element-binding protein 4; hJAL; JAL; mJAL; Processed cyclic AMP-responsive element-binding protein 3-like protein 4; Tisp40; Tisp40alpha; Tisp40beta; Transcript induced in spermiogenesis protein 40;
Immunogens
According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.
- Q8TEY5 CR3L4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDLGIPDLLDAWLEPPEDIFSTGSVLELGLHCPPPEVPVTRLQEQGLQGWKSGGDRGCGLQESEPEDFLKLFIDPNEVYCSEASPGSDSGISEDPCHPDSPPAPRATSSPMLYEVVYEAGALERMQGETGPNVGLISIQLDQWSPAFMVPDSCMVSELPFDAHAHILPRAGTVAPVPCTTLLPCQTLFLTDEEKRLLGQEGVSLPSHLPLTKAEERVLKKVRRKIRNKQSAQDSRRRKKEYIDGLESRVAACSAQNQELQKKVQELERHNISLVAQLRQLQTLIAQTSNKAAQTSTCVLILLFSLALIILPSFSPFQSRPEAGSEDYQPHGVTSRNILTHKDVTENLETQVVESRLREPPGAKDANGSTRTLLEKMGGKPRPSGRIRSVLHADEM
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8TEY5 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K51 | Ubiquitination | Uniprot | |
| S63 | Phosphorylation | Uniprot | |
| S100 | Phosphorylation | Uniprot | |
| S109 | Phosphorylation | Uniprot | |
| Y117 | Phosphorylation | Uniprot | |
| K194 | Ubiquitination | Uniprot | |
| S203 | Phosphorylation | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| K239 | Ubiquitination | Uniprot | |
| K261 | Ubiquitination | Uniprot | |
| K262 | Ubiquitination | Uniprot | |
| T339 | O-Glycosylation | Uniprot | |
| K341 | Ubiquitination | Uniprot | |
| T344 | O-Glycosylation | Uniprot | |
| T349 | O-Glycosylation | Uniprot | |
| S354 | O-Glycosylation | Uniprot | |
| S368 | Phosphorylation | Uniprot | |
| T369 | Phosphorylation | Uniprot | |
| K375 | Acetylation | Uniprot | |
| S388 | Phosphorylation | Uniprot |
Research Backgrounds
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).
N-glycosylated in the C-terminal region.
Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).
Endoplasmic reticulum membrane>Single-pass type II membrane protein. Golgi apparatus membrane>Single-pass type II membrane protein.
Note: May also be located in Golgi apparatus.
Nucleus.
Note: Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
According to exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.
Binds DNA as a dimer.
Belongs to the bZIP family. ATF subfamily.
Research Fields
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > TNF signaling pathway. (View pathway)
· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Human Diseases > Substance dependence > Cocaine addiction.
· Human Diseases > Substance dependence > Amphetamine addiction.
· Human Diseases > Substance dependence > Alcoholism.
· Human Diseases > Infectious diseases: Viral > Hepatitis B.
· Human Diseases > Infectious diseases: Viral > Human papillomavirus infection.
· Human Diseases > Cancers: Overview > Viral carcinogenesis.
· Human Diseases > Cancers: Specific types > Prostate cancer. (View pathway)
· Organismal Systems > Aging > Longevity regulating pathway. (View pathway)
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Nervous system > Cholinergic synapse.
· Organismal Systems > Nervous system > Dopaminergic synapse.
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
· Organismal Systems > Endocrine system > Estrogen signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Melanogenesis.
· Organismal Systems > Endocrine system > Thyroid hormone synthesis.
· Organismal Systems > Endocrine system > Glucagon signaling pathway.
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
· Organismal Systems > Endocrine system > Relaxin signaling pathway.
· Organismal Systems > Excretory system > Vasopressin-regulated water reabsorption.
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