CtBP2 Antibody - #DF8648
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8648, RRID:AB_2841852.
Fold/Unfold
C terminal binding protein 2; C-terminal-binding protein 2; CtBP2; CTBP2_HUMAN; ribeye;
Immunogens
- P56545 CTBP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSAPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLPAAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P56545 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K6 | Acetylation | Uniprot | |
| K8 | Acetylation | Uniprot | |
| K10 | Acetylation | Uniprot | |
| R22 | Methylation | Uniprot | |
| R33 | Methylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| K94 | Ubiquitination | Uniprot | |
| Y108 | Phosphorylation | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| R291 | Methylation | Uniprot | |
| S365 | Phosphorylation | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| T414 | Phosphorylation | Uniprot | |
| S428 | Phosphorylation | Q9H2X6 (HIPK2) | Uniprot |
Research Backgrounds
Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).
Isoform 2 probably acts as a scaffold for specialized synapses.
Nucleus. Cell junction>Synapse.
Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.
Can form homodimers or heterodimers of CTBP1 and CTBP2. Interacts with HIPK2 and ZNF217. Interacts with PRDM16; represses white adipose tissue (WAT)-specific genes expression (By similarity). Interacts with PNN, NRIP1 and WIZ. Interacts with MCRIP1.
(Microbial infection) Interacts with human adenovirus 5 E1A protein; this interaction seems to potentiate viral replication.
Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
Research Fields
· Environmental Information Processing > Signal transduction > Wnt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Notch signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Chronic myeloid leukemia. (View pathway)
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