ALDH3A1 Antibody - #DF8502
| Product: | ALDH3A1 Antibody |
| Catalog: | DF8502 |
| Description: | Rabbit polyclonal antibody to ALDH3A1 |
| Application: | WB IHC |
| Reactivity: | Human, Rat |
| Prediction: | Pig, Bovine, Horse, Dog |
| Mol.Wt.: | 50 kDa; 50kD(Calculated). |
| Uniprot: | P30838 |
| RRID: | AB_2841708 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF8502, RRID:AB_2841708.
Fold/Unfold
Acetaldehyde dehydrogenase 3; AHD 4; AHD C; AHD4; AHDC; AL3A1_HUMAN; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase 3 family member A1; Aldehyde dehydrogenase 3A1; Aldehyde dehydrogenase; Aldehyde dehydrogenase class 3; Aldehyde dehydrogenase dimeric NADP preferring; Aldehyde dehydrogenase family 3 member A1; Aldehyde dehydrogenase family 3 subfamily A1; Aldehyde dehydrogenase family 3, subfamily A, member 1; Aldehyde dehydrogenase isozyme 3; Aldehyde dehydrogenase type III; ALDH 3; ALDH 3A1; ALDH III; ALDH, stomach type; ALDH3 A1; ALDH3; ALDH3A 1; Aldh3a1; ALDHIII; dimeric NADP-preferring; MGC10406; Stomach aldehyde dehydrogenase; Tumor associated aldehyde dehydrogenase tumor ALDH;
Immunogens
- P30838 AL3A1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P30838 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| K3 | Acetylation | Uniprot | |
| S5 | Phosphorylation | Uniprot | |
| Y163 | Phosphorylation | Uniprot | |
| K178 | Acetylation | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| Y186 | Phosphorylation | Uniprot | |
| K194 | Acetylation | Uniprot | |
| T198 | Phosphorylation | Uniprot | |
| K202 | Acetylation | Uniprot | |
| T205 | Phosphorylation | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| K269 | Acetylation | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| Y272 | Phosphorylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| K302 | Ubiquitination | Uniprot | |
| Y305 | Phosphorylation | Uniprot | |
| S399 | Phosphorylation | Uniprot | |
| Y443 | Phosphorylation | Uniprot | |
| S446 | Phosphorylation | Uniprot |
Research Backgrounds
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
Cytoplasm.
High levels in stomach, esophagus and lung; low level in the liver and kidney.
Homodimer.
Belongs to the aldehyde dehydrogenase family.
Research Fields
· Human Diseases > Cancers: Overview > Chemical carcinogenesis.
· Metabolism > Carbohydrate metabolism > Glycolysis / Gluconeogenesis.
· Metabolism > Amino acid metabolism > Histidine metabolism.
· Metabolism > Amino acid metabolism > Tyrosine metabolism.
· Metabolism > Amino acid metabolism > Phenylalanine metabolism.
· Metabolism > Metabolism of other amino acids > beta-Alanine metabolism.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - cytochrome P450.
· Metabolism > Global and overview maps > Metabolic pathways.
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