SSB Antibody - #DF8417

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Product: SSB Antibody
Catalog: DF8417
Description: Rabbit polyclonal antibody to SSB
Application: WB IF/ICC
Reactivity: Human, Mouse
Prediction: Pig, Bovine, Horse, Sheep, Dog
Mol.Wt.: 46 kDa; 47kD(Calculated).
Uniprot: P05455
RRID: AB_2841666

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 100ul $280 In stock
 200ul $350 In stock

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(92%), Bovine(100%), Horse(100%), Sheep(100%), Dog(100%)
Clonality:
Polyclonal
Specificity:
SSB Antibody detects endogenous levels of total SSB.
RRID:
AB_2841666
Cite Format: Affinity Biosciences Cat# DF8417, RRID:AB_2841666.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Autoantigen La; La; La autoantigen; La autoantigen homolog; La protein; La ribonucleoprotein; La ribonucleoprotein domain family member 3; LA_HUMAN; LARP3; Lupus La antigen; Lupus La protein; Lupus La protein homolog; MGC118101; MGC93380; mRNA for autoantigen; OTTMUSP00000014043; RP23 273G23.1; Sjoegren syndrome type B antigen; Sjogren syndrome antigen B (autoantigen La); Sjogren syndrome antigen B; SS B; SS-B; SS-B/La protein; SSB;

Immunogens

Immunogen:
Uniprot:

P05455(LA_HUMAN) >>Visit HPA database.

Gene(ID):
SSB(6741)
Sequence:
MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLLILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKKTKFASDDEHDEHDENGATGPVKRAREETDKEEPASKQQKTENGAGDQ

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Pig
92
Xenopus
67
Chicken
50
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P05455 As Substrate

Site PTM Type Enzyme
K9 Ubiquitination
Y23 Phosphorylation
Y24 Phosphorylation
K37 Ubiquitination
K41 Sumoylation
K41 Ubiquitination
K74 Ubiquitination
K76 Ubiquitination
S83 Phosphorylation
K86 Sumoylation
K86 Ubiquitination
S92 Phosphorylation
S94 Phosphorylation
K95 Acetylation
K95 Ubiquitination
Y104 Phosphorylation
K105 Ubiquitination
K116 Acetylation
K116 Ubiquitination
T120 Phosphorylation
K128 Acetylation
K128 Ubiquitination
K165 Acetylation
K166 Ubiquitination
K174 Ubiquitination
K176 Ubiquitination
T178 Phosphorylation
K185 Acetylation
K185 Sumoylation
Y188 Phosphorylation
K191 Methylation
K200 Sumoylation
K208 Sumoylation
K208 Ubiquitination
K216 Acetylation
K216 Ubiquitination
K224 Ubiquitination
S225 Phosphorylation
K229 Ubiquitination
C232 S-Nitrosylation
K235 Ubiquitination
R266 Methylation
K269 Ubiquitination
K276 Ubiquitination
K280 Acetylation
K285 Acetylation
K287 Ubiquitination
K299 Ubiquitination
T302 Phosphorylation P31749 (AKT1)
K312 Ubiquitination
S325 Phosphorylation
K328 Acetylation
K328 Ubiquitination
K352 Acetylation
K352 Ubiquitination
K354 Acetylation
K354 Ubiquitination
K360 Acetylation
K361 Acetylation
T362 Phosphorylation
S366 Phosphorylation P68400 (CSNK2A1)
T379 Phosphorylation
T389 Phosphorylation
K391 Acetylation
K397 Ubiquitination

Research Backgrounds

Function:

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.

PTMs:

Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.

The N-terminus is blocked.

Subcellular Location:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with DDX15. May interact with RUFY1.

Research Fields

· Human Diseases > Immune diseases > Systemic lupus erythematosus.

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