ES8L2 Antibody - #AF0463
| Product: | ES8L2 Antibody |
| Catalog: | AF0463 |
| Description: | Rabbit polyclonal antibody to ES8L2 |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Zebrafish, Bovine, Horse, Dog, Chicken, Xenopus |
| Mol.Wt.: | 81kDa; 81kD(Calculated). |
| Uniprot: | Q9H6S3 |
| RRID: | AB_2834218 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF0463, RRID:AB_2834218.
Fold/Unfold
Epidermal growth factor receptor kinase substrate 8 like protein 2; Epidermal growth factor receptor kinase substrate 8-like protein 2; Epidermal growth factor receptor pathway substrate 8 like protein 2; Epidermal growth factor receptor pathway substrate 8 related protein 2; Epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8 like 2; EPS8 like protein 2; EPS8 related protein 2; EPS8-like protein 2; EPS8-related protein 2; EPS8L 2; EPS8L2; EPS8R 2; EPS8R2; ES8L2_HUMAN; FLJ16738; FLJ21935; FLJ22171; MGC126530; MGC3088;
Immunogens
- Q9H6S3 ES8L2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRESQEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNKEELKKVCGEEGVRVYSQLTMQKAFLEKQQSGSELEELMNKFHSMNQRRGEDS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9H6S3 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Phosphorylation | Uniprot | |
| S4 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| K30 | Ubiquitination | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| K77 | Ubiquitination | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| S100 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| T125 | Phosphorylation | Uniprot | |
| T184 | Phosphorylation | Uniprot | |
| S197 | Phosphorylation | Uniprot | |
| S217 | Phosphorylation | Uniprot | |
| S231 | Phosphorylation | Uniprot | |
| S240 | Phosphorylation | Uniprot | |
| K251 | Ubiquitination | Uniprot | |
| K275 | Ubiquitination | Uniprot | |
| T303 | Phosphorylation | Uniprot | |
| S368 | Phosphorylation | Uniprot | |
| S449 | Phosphorylation | Uniprot | |
| S455 | Phosphorylation | Uniprot | |
| S459 | Phosphorylation | Uniprot | |
| S463 | Phosphorylation | Uniprot | |
| T465 | Phosphorylation | Uniprot | |
| S466 | Phosphorylation | Uniprot | |
| T469 | Phosphorylation | Uniprot | |
| S479 | Phosphorylation | Uniprot | |
| S480 | Phosphorylation | Uniprot | |
| T483 | Phosphorylation | Uniprot | |
| T490 | Phosphorylation | Uniprot | |
| Y501 | Phosphorylation | Uniprot | |
| S512 | Phosphorylation | Uniprot | |
| Y540 | Phosphorylation | Uniprot | |
| S570 | Phosphorylation | Uniprot | |
| T572 | Phosphorylation | Uniprot | |
| S628 | Phosphorylation | Uniprot | |
| K663 | Acetylation | Uniprot | |
| Y678 | Phosphorylation | Uniprot | |
| K690 | Ubiquitination | Uniprot | |
| S693 | Phosphorylation | Uniprot | |
| S695 | Phosphorylation | Uniprot | |
| K703 | Ubiquitination | Uniprot |
Research Backgrounds
Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity).
Cytoplasm. Cell projection>Stereocilium.
Note: Localizes at the tips of the stereocilia of the inner and outer hair cells.
Detected in fibroblasts and placenta.
Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin.
Belongs to the EPS8 family.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.