TNFRSF6B Antibody - #AF0431

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Product: TNFRSF6B Antibody
Catalog: AF0431
Description: Rabbit polyclonal antibody to TNFRSF6B
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Sheep, Dog
Mol.Wt.: 32kDa; 33kD(Calculated).
Uniprot: O95407
RRID: AB_2834200

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(80%), Bovine(80%), Sheep(82%), Dog(89%)
Clonality:
Polyclonal
Specificity:
TNFRSF6B Antibody detects endogenous levels of total TNFRSF6B.
RRID:
AB_2834200
Cite Format: Affinity Biosciences Cat# AF0431, RRID:AB_2834200.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

DcR3; Decoy receptor 3; Decoy receptor for Fas ligand; DJ583P15.1.1; M68; M68E; OTTHUMP00000031583; TNF6B_HUMAN; TNFRSF6B; TR6; Tumor necrosis factor receptor superfamily member 6B; Tumor necrosis factor receptor superfamily member 6b decoy; UNQ186/PRO212;

Immunogens

Immunogen:
Uniprot:

O95407(TNF6B_HUMAN) >>Visit HPA database.

Gene(ID):
TNFRSF6B(8771)
Expression:
O95407 TNF6B_HUMAN:

Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Description:
TNFRSF6B Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells
Sequence:
MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDAETGERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAFQDISIKRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQALRVARMPGLERSVRERFLPVH

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Dog
89
Sheep
82
Pig
80
Bovine
80
Horse
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - O95407 As Substrate

Site PTM Type Enzyme
R284 Methylation
R290 Methylation
R295 Methylation

Research Backgrounds

Function:

Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Research Fields

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

References

1). DcR3 suppresses the NF-κ B pathway and the NLRP3 inflammasome activation in gouty inflammation. CHINESE MEDICAL JOURNAL, 2024 [IF=7.5]
2). TIPE regulates DcR3 expression and function by activating the PI3K/AKT signaling pathway in CRC. Frontiers in Oncology, 2021 (PubMed: 33718119) [IF=4.7]

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