TTBK2 Antibody - #DF2688
| Product: | TTBK2 Antibody |
| Catalog: | DF2688 |
| Description: | Rabbit polyclonal antibody to TTBK2 |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus |
| Mol.Wt.: | 137 kDa; 137kD(Calculated). |
| Uniprot: | Q6IQ55 |
| RRID: | AB_2839894 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2688, RRID:AB_2839894.
Fold/Unfold
KIAA0847; mKIAA0847; SCA11; Spinocerebellar ataxia 11; Tau tubulin kinase 2; Tau-tubulin kinase 2; TTBK; TTBK 2; TTBK1; TTBK2; TTBK2_HUMAN; TTK;
Immunogens
- Q6IQ55 TTBK2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGGGEQLDILSVGILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIKDKEQVGSIKERYDHRLMLKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDWEKTGNDGSLTTTTTSTTPQLHTRLTPAAIGIANATPIPGDLLRENTDEVFPDEQLSDGENGIPVGVSPDKLPGSLGHPRPQEKDVWEEMDANKNKIKLGICKAATEEENSHGQANGLLNAPSLGSPIRVRSEITQPDRDIPLVRKLRSIHSFELEKRLTLEPKPDTDKFLETCLEKMQKDTSAGKESILPALLHKPCVPAVSRTDHIWHYDEEYLPDASKPASANTPEQADGGGSNGFIAVNLSSCKQEIDSKEWVIVDKEQDLQDFRTNEAVGHKTTGSPSDEEPEVLQVLEASPQDEKLQLGPWAENDHLKKETSGVVLALSAEGPPTAASEQYTDRLELQPGAASQFIAATPTSLMEAQAEGPLTAITIPRPSVASTQSTSGSFHCGQQPEKKDLQPMEPTVELYSPRENFSGLVVTEGEPPSGGSRTDLGLQIDHIGHDMLPNIRESNKSQDLGPKELPDHNRLVVREFENLPGETEEKSILLESDNEDEKLSRGQHCIEISSLPGDLVIVEKDHSATTEPLDVTKTQTFSVVPNQDKNNEIMKLLTVGTSEISSRDIDPHVEGQIGQVAEMQKNKISKDDDIMSEDLPGHQGDLSTFLHQEGKREKITPRNGELFHCVSENEHGAPTRKDMVRSSFVTRHSRIPVLAQEIDSTLESSSPVSAKEKLLQKKAYQPDLVKLLVEKRQFKSFLGDLSSASDKLLEEKLATVPAPFCEEEVLTPFSRLTVDSHLSRSAEDSFLSPIISQSRKSKIPRPVSWVNTDQVNSSTSSQFFPRPPPGKPPTRPGVEARLRRYKVLGSSNSDSDLFSRLAQILQNGSQKPRSTTQCKSPGSPHNPKTPPKSPVVPRRSPSASPRSSSLPRTSSSSPSRAGRPHHDQRSSSPHLGRSKSPPSHSGSSSSRRSCQQEHCKPSKNGLKGSGSLHHHSASTKTPQGKSKPASKLSR
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6IQ55 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K70 | Sumoylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| Y242 | Phosphorylation | Uniprot | |
| T314 | Phosphorylation | Uniprot | |
| T322 | Phosphorylation | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| T402 | Phosphorylation | Uniprot | |
| S407 | Phosphorylation | Uniprot | |
| S428 | Phosphorylation | Uniprot | |
| T431 | Phosphorylation | Uniprot | |
| S445 | Phosphorylation | Uniprot | |
| S448 | Phosphorylation | Uniprot | |
| T463 | Phosphorylation | Uniprot | |
| K476 | Ubiquitination | Uniprot | |
| S479 | Phosphorylation | Uniprot | |
| S499 | Phosphorylation | Uniprot | |
| T613 | Phosphorylation | Uniprot | |
| S614 | Phosphorylation | Uniprot | |
| S621 | Phosphorylation | Uniprot | |
| S751 | Phosphorylation | Uniprot | |
| S781 | Phosphorylation | Uniprot | |
| S786 | Phosphorylation | Uniprot | |
| S794 | Phosphorylation | Uniprot | |
| S817 | Phosphorylation | Uniprot | |
| T828 | Phosphorylation | Uniprot | |
| T830 | Phosphorylation | Uniprot | |
| K845 | Acetylation | Uniprot | |
| K877 | Acetylation | Uniprot | |
| S879 | Phosphorylation | Uniprot | |
| S960 | Phosphorylation | Uniprot | |
| S963 | Phosphorylation | Uniprot | |
| K985 | Ubiquitination | Uniprot | |
| S1039 | Phosphorylation | Uniprot | |
| S1042 | Phosphorylation | Uniprot | |
| S1103 | Phosphorylation | Uniprot | |
| T1139 | Phosphorylation | Uniprot | |
| S1143 | Phosphorylation | Uniprot | |
| S1152 | Phosphorylation | Uniprot | |
| S1154 | Phosphorylation | Uniprot | |
| S1157 | Phosphorylation | Uniprot | |
| S1240 | Phosphorylation | Uniprot | |
| S1243 | Phosphorylation | Uniprot |
PTMs - Q6IQ55 As Enzyme
Research Backgrounds
Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.
Cell projection>Cilium. Cytoplasm>Cytoskeleton>Cilium basal body. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome>Centriole. Cytoplasm>Cytosol. Nucleus.
Note: Localizes to the transition zone in primary cilia in response to cell cycle signals that promote ciliogenesis (By similarity). May also be present in cytosol and, at lower level in the nucleus.
Interacts with CEP164.
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
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