PKN3 Antibody - #DF2678
| Product: | PKN3 Antibody |
| Catalog: | DF2678 |
| Description: | Rabbit polyclonal antibody to PKN3 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Dog |
| Mol.Wt.: | 99kDa,112kDa,104kDa; 99kD(Calculated). |
| Uniprot: | Q6P5Z2 |
| RRID: | AB_2839884 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2678, RRID:AB_2839884.
Fold/Unfold
pkn3; PKN3_HUMAN; PKNBETA; Protein kinase C related kinase 3; Protein kinase N3; Protein kinase PKN beta; Protein kinase PKN-beta; Protein-kinase C-related kinase 3; RP11-545E17.1; Serine/threonine protein kinase N3; Serine/threonine-protein kinase N3;
Immunogens
Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues.
- Q6P5Z2 PKN3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSPAAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q6P5Z2 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K20 | Ubiquitination | Uniprot | |
| K29 | Ubiquitination | Uniprot | |
| R58 | Methylation | Uniprot | |
| T135 | Phosphorylation | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K155 | Ubiquitination | Uniprot | |
| S171 | Phosphorylation | Uniprot | |
| K198 | Ubiquitination | Uniprot | |
| K202 | Ubiquitination | Uniprot | |
| K213 | Ubiquitination | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| S299 | Phosphorylation | Uniprot | |
| S307 | Phosphorylation | Uniprot | |
| S309 | Phosphorylation | Uniprot | |
| S466 | Phosphorylation | Uniprot | |
| S472 | Phosphorylation | Uniprot | |
| T480 | Phosphorylation | Uniprot | |
| S488 | Phosphorylation | Uniprot | |
| T492 | Phosphorylation | Uniprot | |
| S494 | Phosphorylation | Uniprot | |
| K499 | Ubiquitination | Uniprot | |
| T508 | Phosphorylation | Uniprot | |
| K512 | Ubiquitination | Uniprot | |
| T523 | Phosphorylation | Uniprot | |
| S524 | Phosphorylation | Uniprot | |
| T527 | Phosphorylation | Uniprot | |
| S544 | Phosphorylation | Q6P5Z2 (PKN3) | Uniprot |
| S548 | Phosphorylation | Uniprot | |
| T550 | Phosphorylation | Q6P5Z2 (PKN3) | Uniprot |
| K583 | Acetylation | Uniprot | |
| K583 | Ubiquitination | Uniprot | |
| K588 | Ubiquitination | Uniprot | |
| K592 | Ubiquitination | Uniprot | |
| K686 | Ubiquitination | Uniprot | |
| T716 | Phosphorylation | Uniprot | |
| S717 | Phosphorylation | Uniprot | |
| T718 | Phosphorylation | Uniprot | |
| T722 | Phosphorylation | Uniprot | |
| K796 | Ubiquitination | Uniprot | |
| K813 | Ubiquitination | Uniprot | |
| T820 | Phosphorylation | Uniprot | |
| T860 | Phosphorylation | Uniprot |
PTMs - Q6P5Z2 As Enzyme
Research Backgrounds
Contributes to invasiveness in malignant prostate cancer.
Autophosphorylated.
Nucleus. Cytoplasm>Perinuclear region.
Note: Nuclear and perinuclear Golgi region.
Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues.
The C1 domain does not bind the diacylglycerol (DAG).
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Research Fields
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Salmonella infection.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.