HUWE1 Antibody - #DF2628

(1)  
Product: HUWE1 Antibody
Catalog: DF2628
Description: Rabbit polyclonal antibody to HUWE1
Application: WB
Reactivity: Human, Mouse
Prediction: Rabbit
Mol.Wt.: 481 kDa; 482kD(Calculated).
Uniprot: Q7Z6Z7
RRID: AB_2839834

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IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Rabbit(92%)
Clonality:
Polyclonal
Specificity:
HUWE1 Antibody detects endogenous levels of total HUWE1.
RRID:
AB_2839834
Cite Format: Affinity Biosciences Cat# DF2628, RRID:AB_2839834.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ARF binding protein 1; ARF BP1; ARF-binding protein 1; ARF-BP1; BJ-HCC-24 tumor antigen; E3 ubiquitin protein ligase HUWE1; E3 ubiquitin-protein ligase HUWE1; HECT; HECT domain protein LASU1; HECT UBA and WWE domain containing protein 1; HectH9; Homologous to E6AP carboxyl terminus homologous protein 9; Huwe1; HUWE1_HUMAN; Ib772; Large structure of UREB1; LASU1; Mcl 1 ubiquitin ligase E3; Mcl-1 ubiquitin ligase E3; Mule; UBA and WWE domain-containing protein 1; Upstream regulatory element-binding protein 1; URE-B1; URE-binding protein 1; UREB1;

Immunogens

Immunogen:
Uniprot:

Q7Z6Z7(HUWE1_HUMAN) >>Visit HPA database.

Gene(ID):
HUWE1(10075)
Expression:
Q7Z6Z7 HUWE1_HUMAN:

Weakly expressed in heart, brain and placenta but not in other tissues. Expressed in a number of cell lines, predominantly in those from colorectal carcinomas.

Description:
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.
Sequence:
MKVDRTKLKKTPTEAPADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADAGQTVENMSWMLVCDRPEREQLKMLLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKRSNYITRLGSDKRTPLLTRLQHLAESWGGKENGFGLAECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIMESLTKMYSIPKDKQMLLFTHIRLAHGFSNHRKRLQAVQARLHAISILVYSNALQESANSILYNGLIEELVDVLQITDKQLMEIKAASLRTLTSIVHLERTPKLSSIIDCTGTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALLKVIKFLGDEQDQITFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRKECPFVIKPKIQRPNTTQEGEEMETDMDGVQCIPQRAALLKSMLNFLKKAIQDPAFSDGIRHVMDGSLPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKADGTATAPPPRSNHAAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDYILNVMKFVESILSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTLSHEPKVLQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPLLHALTAAHAYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLYCSLVWESTVLLSLCTPNSLPSGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLAPMETDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQRRSHHAASTTTAPTPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTFFICSVGFTSPMLFDERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDAWLMLVEKMVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKNLWNRKPLKVYGGRMAESMLAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHPPPIMGGVVRDLSMSEEDQMMRAIAMSLGQDIPMDQRAESPEEVACRKEEEERKAREKQEEEEAKCLEKFQDADPLEQDELHTFTDTMLPGCFHLLDELPDTVYRVCDLIMTAIKRNGADYRDMILKQVVNQVWEAADVLIKAALPLTTSDTKTVSEWISQMATLPQASNLATRILLLTLLFEELKLPCAWVVESSGILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPVLLLIDFYEKTAISSKRRAQMTKYLQSNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPVMLTLLRVPRLNKNSKNSNGQELEKTLEESKEMDIKRKENKGNDTPLALESTNTEKETSLEETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLHATLRLCLRLTRDHKYAMMFAELKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALPAPRGSGTASDDEFENLRIKGPNAVQLVKTTPLKPSPLPVIPDTIKEVIYDMLNALAAYHAPEEADKSDPKPGVMTQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFSINSQVFAADGASTETSASGTSQGEASTPEESRDGKKDKEGDRASEEGKQKGKGSKPLMPTSTILRLLAELVRSYVGIATLIANYSYTVGQSELIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAAGSGTDAQVALVNEVKAALGRALAMAESTEKHARLQAVMCIISTIMESCPSTSSFYSSATAKTQHNGMNNIIRLFLKKGLVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQPSSLFGSKSASSKNKSEQDAQGASQDSSSNQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQEMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEGDEDDDDDGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTHPLMVRHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRLLGPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDELLDDFFHDQSTATSQAGTLSSIPTALTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERREKRRKQLAEEETKITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSSEQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPSTNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPVTFIQTLPSDLRRSVLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSSTSALSAILRSPAFTSRLSGNRGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRLRGRLLLDHEALSCLLVLLFVDEPKLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSSESELCIETPKLTTSEEKGKKSSKSCGSSSHENRPLDLLHKMESKSSNQLSWLSVSMDAALGCRTNIFQIQRSGGRKHTEKHASGGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQQRTKETNCESDRERGNKACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSAGGEGETSPYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENKVSEAQANSGSGASSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVAASTTVTTPTTATTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLEDAANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGTLLAELREYNLEQQRRAQCETLSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQKFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQMVREGQRARRQQQAATSESSQSEASVRREESPMDVDQPSPSAQDTQSIASDGTPQGEKEKEERPPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPPVRDTRESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAETHRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
92
Zebrafish
75
Pig
0
Horse
0
Bovine
0
Sheep
0
Dog
0
Xenopus
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q7Z6Z7 As Substrate

Site PTM Type Enzyme
K10 Ubiquitination
K25 Ubiquitination
K27 Ubiquitination
K173 Ubiquitination
K190 Ubiquitination
K231 Ubiquitination
K245 Ubiquitination
K251 Ubiquitination
T259 Phosphorylation
K324 Ubiquitination
T330 Phosphorylation
T332 Phosphorylation
S333 Phosphorylation
K342 Ubiquitination
R468 Methylation
K476 Ubiquitination
T484 Phosphorylation
T485 Phosphorylation
K509 Acetylation
K509 Ubiquitination
K516 Ubiquitination
K517 Ubiquitination
S525 Phosphorylation
R529 Methylation
K632 Ubiquitination
S636 Phosphorylation
S648 Phosphorylation
S649 Phosphorylation
T655 Phosphorylation
S657 Phosphorylation
K674 Ubiquitination
K696 Ubiquitination
K701 Ubiquitination
S726 Phosphorylation
S727 Phosphorylation
S740 Phosphorylation
K797 Ubiquitination
S830 Phosphorylation
S927 Phosphorylation Q13315 (ATM)
K1037 Ubiquitination
T1039 Phosphorylation
K1050 Ubiquitination
S1077 Phosphorylation
S1084 Phosphorylation
T1090 Phosphorylation
T1092 Phosphorylation
K1107 Ubiquitination
K1111 Ubiquitination
K1147 Ubiquitination
K1156 Ubiquitination
S1160 Phosphorylation
T1169 Phosphorylation
S1218 Phosphorylation
K1225 Ubiquitination
K1247 Ubiquitination
K1254 Ubiquitination
K1295 Ubiquitination
S1298 Phosphorylation
Y1351 Phosphorylation
T1354 Phosphorylation
S1368 Phosphorylation
S1370 Phosphorylation
S1382 Phosphorylation
S1395 Phosphorylation
C1401 S-Nitrosylation
K1403 Ubiquitination
K1413 Ubiquitination
K1420 Ubiquitination
C1421 S-Nitrosylation
K1424 Ubiquitination
K1470 Ubiquitination
Y1476 Phosphorylation
K1482 Acetylation
T1509 Phosphorylation
S1511 Phosphorylation
T1519 Phosphorylation
K1572 Ubiquitination
K1601 Ubiquitination
K1608 Ubiquitination
K1643 Ubiquitination
Y1658 Phosphorylation
K1693 Ubiquitination
K1702 Ubiquitination
T1703 Phosphorylation
S1707 Phosphorylation
K1708 Ubiquitination
K1713 Ubiquitination
K1718 Ubiquitination
T1722 Phosphorylation
T1729 Phosphorylation
T1731 Phosphorylation
K1733 Ubiquitination
T1735 Phosphorylation
S1736 Phosphorylation
K1799 Ubiquitination
K1840 Acetylation
K1840 Ubiquitination
S1852 Phosphorylation
S1859 Phosphorylation
Y1869 Phosphorylation
R1901 Methylation
S1903 Phosphorylation
T1905 Phosphorylation
S1907 Phosphorylation
K1917 Ubiquitination
K1926 Ubiquitination
T1927 Phosphorylation
T1928 Phosphorylation
K1931 Acetylation
K1931 Ubiquitination
K1968 Ubiquitination
Y1988 Phosphorylation
Y1991 Phosphorylation
T1995 Phosphorylation
S1998 Phosphorylation
S1999 Phosphorylation
T2035 Phosphorylation
K2046 Ubiquitination
S2052 Phosphorylation
K2060 Acetylation
T2068 Phosphorylation
S2069 Phosphorylation
T2070 Phosphorylation
K2157 Ubiquitination
K2172 Ubiquitination
Y2197 Phosphorylation
S2198 Phosphorylation
K2218 Ubiquitination
K2219 Ubiquitination
K2248 Acetylation
K2248 Ubiquitination
S2261 Phosphorylation
S2262 Phosphorylation
S2266 Phosphorylation
K2267 Ubiquitination
S2339 Phosphorylation Q13315 (ATM)
S2362 Phosphorylation
S2365 Phosphorylation
T2366 Phosphorylation
S2370 Phosphorylation
S2372 Phosphorylation
S2377 Phosphorylation
S2388 Phosphorylation
S2391 Phosphorylation Q13535 (ATR)
S2394 Phosphorylation
T2395 Phosphorylation
Y2471 Phosphorylation
S2526 Phosphorylation
S2527 Phosphorylation
T2529 Phosphorylation
S2532 Phosphorylation
S2534 Phosphorylation
S2535 Phosphorylation
T2536 Phosphorylation
T2537 Phosphorylation
T2540 Phosphorylation
R2545 Methylation
S2546 Phosphorylation
T2554 Phosphorylation
S2584 Phosphorylation
S2593 Phosphorylation
S2594 Phosphorylation
S2595 Phosphorylation
S2600 Phosphorylation
S2619 Phosphorylation
S2632 Phosphorylation
T2635 Phosphorylation
S2636 Phosphorylation Q13315 (ATM)
K2656 Ubiquitination
K2671 Ubiquitination
R2682 Methylation
K2695 Ubiquitination
K2703 Ubiquitination
T2705 Phosphorylation
K2709 Ubiquitination
K2712 Ubiquitination
S2718 Phosphorylation
K2725 Ubiquitination
S2735 Phosphorylation
T2738 Phosphorylation
S2743 Phosphorylation
T2746 Phosphorylation
T2747 Phosphorylation
T2751 Phosphorylation
S2826 Phosphorylation
S2833 Phosphorylation
S2835 Phosphorylation
S2842 Phosphorylation
T2846 Phosphorylation
S2855 Phosphorylation
S2861 Phosphorylation
S2887 Phosphorylation
S2888 Phosphorylation
T2889 Phosphorylation
S2917 Phosphorylation
S2918 Phosphorylation
S2923 Phosphorylation
S2927 Phosphorylation
T2928 Phosphorylation
S2936 Phosphorylation
S2940 Phosphorylation
S2950 Phosphorylation
T2951 Phosphorylation
S3072 Phosphorylation
S3116 Phosphorylation
S3117 Phosphorylation
T3118 Phosphorylation
S3122 Phosphorylation
S3127 Phosphorylation
S3132 Phosphorylation
S3135 Phosphorylation
R3138 Methylation
Y3142 Phosphorylation
T3143 Phosphorylation
R3149 Methylation
S3158 Phosphorylation
S3165 Phosphorylation
S3167 Phosphorylation
T3171 Phosphorylation
S3225 Phosphorylation
K3244 Ubiquitination
T3246 Phosphorylation
T3247 Phosphorylation
K3251 Ubiquitination
K3257 Ubiquitination
S3261 Phosphorylation
K3274 Ubiquitination
K3314 Ubiquitination
K3345 Ubiquitination
K3357 Ubiquitination
K3370 Ubiquitination
S3373 Phosphorylation
S3377 Phosphorylation Q13315 (ATM)
K3409 Ubiquitination
Y3424 Phosphorylation
S3447 Phosphorylation
K3452 Ubiquitination
S3553 Phosphorylation
S3555 Phosphorylation
K3558 Ubiquitination
S3560 Phosphorylation
K3621 Ubiquitination
K3636 Ubiquitination
C3658 S-Nitrosylation
S3662 Phosphorylation
K3675 Ubiquitination
K3677 Ubiquitination
S3695 Phosphorylation Q13315 (ATM)
K3697 Ubiquitination
K3716 Ubiquitination
K3721 Ubiquitination
T3747 Phosphorylation
S3752 Phosphorylation
S3753 Phosphorylation
S3757 Phosphorylation
S3759 Phosphorylation
S3760 Phosphorylation
T3793 Phosphorylation
S3794 Phosphorylation
S3797 Phosphorylation Q13315 (ATM)
S3808 Phosphorylation
S3816 Phosphorylation
S3818 Phosphorylation
T3822 Phosphorylation
S3824 Phosphorylation
S3827 Phosphorylation
T3830 Phosphorylation
K3835 Ubiquitination
R3840 Methylation
S3906 Phosphorylation
K3912 Ubiquitination
S3919 Phosphorylation
T3924 Phosphorylation
T3927 Phosphorylation
S3929 Phosphorylation
S3930 Phosphorylation
S3947 Phosphorylation
K3954 Ubiquitination
T3975 Phosphorylation
K3997 Ubiquitination
K4014 Ubiquitination
K4037 Acetylation
Y4066 Phosphorylation
Y4078 Phosphorylation
T4083 Phosphorylation
S4084 Phosphorylation
K4116 Ubiquitination
K4139 Ubiquitination
K4190 Ubiquitination
K4221 Ubiquitination
Y4271 Phosphorylation
K4295 Ubiquitination
T4301 Phosphorylation
S4304 Phosphorylation
K4305 Ubiquitination
K4322 Ubiquitination

Research Backgrounds

Function:

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4. Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1.

PTMs:

Phosphorylated on tyrosine; phosphorylation is probably required for its ability to inhibit TP53 transactivation.

Subcellular Location:

Cytoplasm. Nucleus.
Note: Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells (By similarity). Predominantly cytosolic or perinuclear in some colorectal carcinoma cells.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Weakly expressed in heart, brain and placenta but not in other tissues. Expressed in a number of cell lines, predominantly in those from colorectal carcinomas.

Subunit Structure:

Interacts with isoform p14ARF of CDKN2A which strongly inhibits HUWE1 ubiquitin ligase activity. Interacts with MYCN, POLB and CDC6. Interacts with isoform 2 of PA2G4. Interacts with NR1D1.

Family&Domains:

The HECT domain mediates inhibition of the transcriptional activity of p53.

Belongs to the UPL family. TOM1/PTR1 subfamily.

Research Fields

· Genetic Information Processing > Folding, sorting and degradation > Ubiquitin mediated proteolysis.   (View pathway)

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