INT6 Antibody - #DF2482
| Product: | INT6 Antibody |
| Catalog: | DF2482 |
| Description: | Rabbit polyclonal antibody to INT6 |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 117 kDa; 100kD(Calculated). |
| Uniprot: | Q9UL03 |
| RRID: | AB_2839688 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2482, RRID:AB_2839688.
Fold/Unfold
DBI 1; DBI-1; DBI1; DDX26; DDX26A; DEAD box protein; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 26; Deleted in cancer 1; DICE1; DKFZp434B105; HDB; Int6; INT6_HUMAN; Integrator complex subunit 6; INTS 6; ints6; Notchl2; OTTHUMP00000018439; OTTHUMP00000215034; OTTHUMP00000215036; Protein DDX26; Protein deleted in cancer 1; RNA helicase HDB;
Immunogens
Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
- Q9UL03 INT6_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPSPVEDGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYSELGHPFGYLKASTALNCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAYRKDFQQLLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRRFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPNMQGIPKRRRCMSPLLRGRQQNPVVNNHIGGKGPPAPTTQAQPDLIKPLPLHKISETTNDSIIHDVVENHVADQLSSDITPNAMDTEFSASSPASLLERPTNHMEALGHDHLGTNDLTVGGFLENHEEPRDKEQCAEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UL03 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K37 | Ubiquitination | Uniprot | |
| S150 | Phosphorylation | Uniprot | |
| K159 | Ubiquitination | Uniprot | |
| T297 | Phosphorylation | Uniprot | |
| K326 | Ubiquitination | Uniprot | |
| Y446 | Phosphorylation | Uniprot | |
| Y450 | Phosphorylation | Uniprot | |
| S451 | Phosphorylation | Uniprot | |
| Y455 | Phosphorylation | Uniprot | |
| K458 | Ubiquitination | Uniprot | |
| K477 | Ubiquitination | Uniprot | |
| T482 | Phosphorylation | Uniprot | |
| K485 | Ubiquitination | Uniprot | |
| Y497 | Phosphorylation | Uniprot | |
| K499 | Ubiquitination | Uniprot | |
| Y545 | Phosphorylation | Uniprot | |
| K572 | Ubiquitination | Uniprot | |
| K595 | Ubiquitination | Uniprot | |
| S599 | Phosphorylation | Uniprot | |
| T614 | Phosphorylation | Uniprot | |
| S661 | Phosphorylation | Uniprot | |
| K695 | Acetylation | Uniprot | |
| K695 | Ubiquitination | Uniprot | |
| S792 | Phosphorylation | Uniprot | |
| K795 | Ubiquitination | Uniprot | |
| S804 | Phosphorylation | Uniprot | |
| S886 | Phosphorylation | Uniprot |
Research Backgrounds
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth.
Nucleus.
Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
Belongs to the Integrator subunit 6 family.
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