AEBP1 Antibody - #DF2427
| Product: | AEBP1 Antibody |
| Catalog: | DF2427 |
| Description: | Rabbit polyclonal antibody to AEBP1 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Horse, Sheep, Rabbit, Dog, Xenopus |
| Mol.Wt.: | 130kDa; 131kD(Calculated). |
| Uniprot: | Q8IUX7 |
| RRID: | AB_2839633 |
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Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2427, RRID:AB_2839633.
Immunogens
- Q8IUX7 AEBP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAVRGAPLLSCLLALLALCPGGRPQTVLTDDEIEEFLEGFLSELEPEPREDDVEAPPPPEPTPRVRKAQAGGKPGKRPGTAAEVPPEKTKDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPPSGKRPPILAPSETLEWPLPPPPSPGPEELPQEGGAPLSNNWQNPGEETHVEAREHQPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRRPERVWPEPPEEKAPAPAPEERIEPPVKPLLPPLPPDYGDGYVIPNYDDMDYYFGPPPPQKPDAERQTDEEKEELKKPKKEDSSPKEETDKWAVEKGKDHKEPRKGEELEEEWTPTEKVKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCSVAPVYSYYAQNEVVATDDLDFRHHSYKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPTQEQLLAAAMAAARGEDEDEVSEAQETPDHAIFRWLAISFASAHLTLTEPYRGGCQAQDYTGGMGIVNGAKWNPRTGTINDFSYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSAKTCNVDYDIGATQCNFILARSNWKRIREIMAMNGNRPIPHIDPSRPMTPQQRRLQQRRLQHRLRLRAQMRLRRLNATTTLGPHTVPPTLPPAPATTLSTTIEPWGLIPPTTAGWEESETETYTEVVTEFGTEVEPEFGTKVEPEFETQLEPEFETQLEPEFEEEEEEEKEEEIATGQAFPFTTVETYTVNFGDF
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8IUX7 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K95 | Acetylation | Uniprot | |
| K96 | Acetylation | Uniprot | |
| S109 | Phosphorylation | Uniprot | |
| S113 | Phosphorylation | Uniprot | |
| K134 | Acetylation | Uniprot | |
| K137 | Acetylation | Uniprot | |
| K145 | Acetylation | Uniprot | |
| K148 | Acetylation | Uniprot | |
| K156 | Acetylation | Uniprot | |
| K159 | Acetylation | Uniprot | |
| T228 | Phosphorylation | Uniprot | |
| T232 | Phosphorylation | Uniprot | |
| S347 | Phosphorylation | Uniprot | |
| S404 | Phosphorylation | Uniprot | |
| Y429 | Phosphorylation | Uniprot | |
| N528 | N-Glycosylation | Uniprot | |
| K575 | Ubiquitination | Uniprot | |
| K592 | Ubiquitination | Uniprot | |
| K598 | Acetylation | Uniprot | |
| T621 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| K716 | Ubiquitination | Uniprot | |
| K894 | Ubiquitination | Uniprot | |
| N922 | N-Glycosylation | Uniprot | |
| T1012 | Phosphorylation | P28482 (MAPK1) | Uniprot |
Research Backgrounds
As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix.
May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.
Phosphorylated by MAPK1 in vitro.
Secreted.
Cytoplasm. Nucleus.
Expressed in osteoblast and visceral fat.
Isoform 1: Interacts with different types of collagen, including collagens I, III, and V. Isoform 2: Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN. Interaction with MAPK1 may stimulate DNA-binding. May interact with calmodulin. Binds to DNA in vitro.
The F5/8 type C domain binds to different types of collagen, including collagens I, III, and V.
Belongs to the peptidase M14 family.
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