CCNL2 Antibody - #DF2287
| Product: | CCNL2 Antibody |
| Catalog: | DF2287 |
| Description: | Rabbit polyclonal antibody to CCNL2 |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 58 kDa; 58kD(Calculated). |
| Uniprot: | Q96S94 |
| RRID: | AB_2839513 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2287, RRID:AB_2839513.
Fold/Unfold
ANIA-6B; CCNM; HLA-ISO; PCEE; SB138;
Immunogens
- Q96S94 CCNL2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAAAAAAGAAGSAAPAAAAGAPGSGGAPSGSQGVLIGDRLYSGVLITLENCLLPDDKLRFTPSMSSGLDTDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHLASKIEEAPRRIRDVINVFHRLRQLRDKKKPVPLLLDQDYVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTSWNYMNDSLRTDVFVRFQPESIACACIYLAARTLEIPLPNRPHWFLLFGATEEEIQEICLKILQLYARKKVDLTHLEGEVEKRKHAIEEAKAQARGLLPGGTQVLDGTSGFSPAPKLVESPKEGKGSKPSPLSVKNTKRRLEGAKKAKADSPVNGLPKGRESRSRSRSREQSYSRSPSRSASPKRRKSDSGSTSGGSKSQSRSRSRSDSPPRQAPRSAPYKGSEIRGSRKSKDCKYPQKPHKSRSRSSSRSRSRSRERADNPGKYKKKSHYYRDQRRERSRSYERTGRRYERDHPGHSRHRR
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q96S94 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S25 | Phosphorylation | Uniprot | |
| T101 | Phosphorylation | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| K288 | Ubiquitination | Uniprot | |
| K309 | Ubiquitination | Uniprot | |
| T326 | Phosphorylation | Uniprot | |
| S327 | Phosphorylation | Uniprot | |
| S330 | Phosphorylation | Q13627 (DYRK1A) | Uniprot |
| S338 | Phosphorylation | Q13627 (DYRK1A) | Uniprot |
| S345 | Phosphorylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| S351 | Phosphorylation | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| K366 | Ubiquitination | Uniprot | |
| S369 | Phosphorylation | Q13627 (DYRK1A) | Uniprot |
| S400 | Phosphorylation | Uniprot | |
| S423 | Phosphorylation | Uniprot | |
| S425 | Phosphorylation | Uniprot | |
| S427 | Phosphorylation | Uniprot | |
| S435 | Phosphorylation | Uniprot | |
| S441 | Phosphorylation | Uniprot | |
| S461 | Phosphorylation | Uniprot | |
| K482 | Acetylation | Uniprot | |
| Y483 | Phosphorylation | Uniprot | |
| S498 | Phosphorylation | Uniprot | |
| S500 | Phosphorylation | Uniprot | |
| S516 | Phosphorylation | Uniprot |
Research Backgrounds
Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.
Nucleus speckle. Nucleus>Nucleoplasm.
Widely expressed.
Interacts with CDK11A, CDK11B, CDK12, CDK13 and POLR2A, the hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II. May form a ternary complex with CDK11B and casein kinase II (CKII). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7.
Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity).
Belongs to the cyclin family. Cyclin L subfamily.
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