GPSN2 Antibody - #DF2247

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Product: GPSN2 Antibody
Catalog: DF2247
Description: Rabbit polyclonal antibody to GPSN2
Application: WB IHC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Dog, Chicken, Xenopus
Mol.Wt.: 36 kDa; 36kD(Calculated).
Uniprot: Q9NZ01
RRID: AB_2839478

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(92%), Horse(100%), Dog(100%), Chicken(100%), Xenopus(83%)
Clonality:
Polyclonal
Specificity:
GPSN2 Antibody detects endogenous levels of total GPSN2.
RRID:
AB_2839478
Cite Format: Affinity Biosciences Cat# DF2247, RRID:AB_2839478.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

2410016D23Rik; A230102P12Rik; AI173355; D17Ertd178e; Glycoprotein synaptic 2; Gpsn2; Neuroprotective protein 13; SC2; Synaptic glycoprotein SC2; Tecr; TER; Trans 2,3 enoyl CoA reductase;

Immunogens

Immunogen:
Uniprot:

Q9NZ01(TECR_HUMAN) >>Visit HPA database.

Gene(ID):
TECR(9524)
Expression:
Q9NZ01 TECR_HUMAN:

Expressed in most tissues tested. Highly expressed in skeletal muscle.

Sequence:
MKHYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Dog
100
Chicken
100
Bovine
92
Xenopus
83
Rabbit
36
Sheep
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9NZ01 As Substrate

Site PTM Type Enzyme
K2 Acetylation
K2 Ubiquitination
Y4 Phosphorylation
K12 Acetylation
K12 Ubiquitination
K16 Ubiquitination
K22 Acetylation
K22 Ubiquitination
T28 Phosphorylation
K33 Ubiquitination
K38 Acetylation
K38 Ubiquitination
S49 Phosphorylation
K57 Ubiquitination
S58 Phosphorylation
K60 Acetylation
K60 Ubiquitination
K67 Ubiquitination
K116 Ubiquitination
T145 Phosphorylation
K224 Ubiquitination
K227 Ubiquitination
K291 Ubiquitination

Research Backgrounds

Function:

Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway. Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA.

PTMs:

Glycosylated.

Subcellular Location:

Endoplasmic reticulum membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in most tissues tested. Highly expressed in skeletal muscle.

Subunit Structure:

Interacts with ELOVL1 and LASS2.

Family&Domains:

Belongs to the steroid 5-alpha reductase family.

Research Fields

· Metabolism > Lipid metabolism > Fatty acid elongation.

· Metabolism > Lipid metabolism > Biosynthesis of unsaturated fatty acids.

· Metabolism > Global and overview maps > Fatty acid metabolism.

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