KCNN1 Antibody - #DF2237

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Product: KCNN1 Antibody
Catalog: DF2237
Description: Rabbit polyclonal antibody to KCNN1
Application: WB IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Horse, Sheep, Dog
Mol.Wt.: 60 kDa; 60kD(Calculated).
Uniprot: Q92952
RRID: AB_2839468

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(92%), Horse(92%), Sheep(100%), Dog(92%)
Clonality:
Polyclonal
Specificity:
KCNN1 Antibody detects endogenous levels of total KCNN1.
RRID:
AB_2839468
Cite Format: Affinity Biosciences Cat# DF2237, RRID:AB_2839468.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

hSK1; KCa2.1; KCNN 1; Kcnn1; KCNN1_HUMAN; Potassium intermediate/small conductance calcium activated channel subfamily N member 1; SK; SK1; SKCa 1; SKCa1; Small conductance calcium activated potassium channel protein 1; Small conductance calcium-activated potassium channel protein 1;

Immunogens

Immunogen:
Uniprot:

Q92952(KCNN1_HUMAN) >>Visit HPA database.

Gene(ID):
KCNN1(3780)
Description:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin
Sequence:
MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPRGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Sheep
100
Pig
92
Horse
92
Dog
92
Chicken
77
Bovine
0
Xenopus
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q92952 As Substrate

Site PTM Type Enzyme
S16 Phosphorylation
S107 Phosphorylation
Y109 Phosphorylation P00533 (EGFR)
K373 Ubiquitination
T409 Phosphorylation

Research Backgrounds

Function:

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).

Subcellular Location:

Membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

Family&Domains:

Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.

Research Fields

· Organismal Systems > Endocrine system > Insulin secretion.   (View pathway)

References

1). Roles of nucleus accumbens shell small-conductance calcium-activated potassium channels in the conditioned fear freezing. Journal of Psychiatric Research, 2023 (PubMed: 37216772) [IF=4.8]

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