SH3BP2 Antibody - #DF2236
| Product: | SH3BP2 Antibody |
| Catalog: | DF2236 |
| Description: | Rabbit polyclonal antibody to SH3BP2 |
| Application: | WB IHC |
| Reactivity: | Human |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| Mol.Wt.: | 62,85kD; 62kD(Calculated). |
| Uniprot: | P78314 |
| RRID: | AB_2839467 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF2236, RRID:AB_2839467.
Fold/Unfold
3BP-2; 3BP2; 3BP2_HUMAN; Abl SH3 binding protein 2; Cherubism; CRBM; CRPM; FLJ42079; FLJ54978; RES4-23; SH3 domain binding protein 2; SH3 domain-binding protein 2; Sh3bp2; TNFAIP3 interacting protein 2;
Immunogens
Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.
- P78314 3BP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAEEMHWPVPMKAIGAQNLLTMPGGVAKAGYLHKKGGTQLQLLKWPLRFVIIHKRCVYYFKSSTSASPQGAFSLSGYNRVMRAAEETTSNNVFPFKIIHISKKHRTWFFSASSEEERKSWMALLRREIGHFHEKKDLPLDTSDSSSDTDSFYGAVERPVDISLSPYPTDNEDYEHDDEDDSYLEPDSPEPGRLEDALMHPPAYPPPPVPTPRKPAFSDMPRAHSFTSKGPGPLLPPPPPKHGLPDVGLAAEDSKRDPLCPRRAEPCPRVPATPRRMSDPPLSTMPTAPGLRKPPCFRESASPSPEPWTPGHGACSTSSAAIMATATSRNCDKLKSFHLSPRGPPTSEPPPVPANKPKFLKIAEEDPPREAAMPGLFVPPVAPRPPALKLPVPEAMARPAVLPRPEKPQLPHLQRSPPDGQSFRSFSFEKPRQPSQADTGGDDSDEDYEKVPLPNSVFVNTTESCEVERLFKATSPRGEPQDGLYCIRNSSTKSGKVLVVWDETSNKVRNYRIFEKDSKFYLEGEVLFVSVGSMVEHYHTHVLPSHQSLLLRHPYGYTGPR
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P78314 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K29 | Ubiquitination | Uniprot | |
| T39 | Phosphorylation | Uniprot | |
| Y174 | Phosphorylation | P43405 (SYK) | Uniprot |
| Y183 | Phosphorylation | P43405 (SYK) | Uniprot |
| S218 | Phosphorylation | Uniprot | |
| S225 | Phosphorylation | Uniprot | |
| S228 | Phosphorylation | Uniprot | |
| T273 | Phosphorylation | Uniprot | |
| S278 | Phosphorylation | Uniprot | |
| T284 | Phosphorylation | Uniprot | |
| S336 | Phosphorylation | Uniprot | |
| S340 | Phosphorylation | Uniprot | |
| K361 | Ubiquitination | Uniprot | |
| S416 | Phosphorylation | Uniprot | |
| S425 | Phosphorylation | Uniprot | |
| S427 | Phosphorylation | Uniprot | |
| K430 | Ubiquitination | Uniprot | |
| S444 | Phosphorylation | Uniprot | |
| Y448 | Phosphorylation | P43405 (SYK) | Uniprot |
Research Backgrounds
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
Phosphorylated. Phosphorylation at Tyr-448 may stimulate the activity of the LYN kinase (By similarity).
Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.
Research Fields
· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity. (View pathway)
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