PEX1 Antibody - #DF2221

(2)  
Product: PEX1 Antibody
Catalog: DF2221
Description: Rabbit polyclonal antibody to PEX1
Application: WB IHC
Reactivity: Human, Mouse
Mol.Wt.: 142 kDa; 143kD(Calculated).
Uniprot: O43933
RRID: AB_2839452

View similar products>>

   Size Price Inventory
 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

For pricing and ordering contact:
Local distributors
Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
PEX1 Antibody detects endogenous levels of total PEX1.
RRID:
AB_2839452
Cite Format: Affinity Biosciences Cat# DF2221, RRID:AB_2839452.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Highly similar to ATPase [H.sapiens]; Peroxin 1; Peroxin-1; peroxin1; Peroxisome biogenesis disorder protein 1; Peroxisome biogenesis factor 1; PEX1; PEX1_HUMAN; ZWS1;

Immunogens

Immunogen:

A synthesized peptide derived from human PEX1, corresponding to a region within N-terminal amino acids.

Uniprot:

O43933(PEX1_HUMAN) >>Visit HPA database.

Gene(ID):
PEX1(5189)
Description:
Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.
Sequence:
MWGSDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQNQAIEVVWSHQPAFLSWVEGRHFSDQGENVAEINRQVGQKLGLSNGGQVFLKPCSHVVSCQQVEVEPLSADDWEILELHAVSLEQHLLDQIRIVFPKAIFPVWVDQQTYIFIQIVALIPAASYGRLETDTKLLIQPKTRRAKENTFSKADAEYKKLHSYGRDQKGMMKELQTKQLQSNTVGITESNENESEIPVDSSSVASLWTMIGSIFSFQSEKKQETSWGLTEINAFKNMQSKVVPLDNIFRVCKSQPPSIYNASATSVFHKHCAIHVFPWDQEYFDVEPSFTVTYGKLVKLLSPKQQQSKTKQNVLSPEKEKQMSEPLDQKKIRSDHNEEDEKACVLQVVWNGLEELNNAIKYTKNVEVLHLGKVWIPDDLRKRLNIEMHAVVRITPVEVTPKIPRSLKLQPRENLPKDISEEDIKTVFYSWLQQSTTTMLPLVISEEEFIKLETKDGLKEFSLSIVHSWEKEKDKNIFLLSPNLLQKTTIQVLLDPMVKEENSEEIDFILPFLKLSSLGGVNSLGVSSLEHITHSLLGRPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAKETGGFVARDFTVLVDRAIHSRLSRQSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDLSLSSMVFLNHSSGSDDSAGDGECGLDQSLVSLEMSEILPDESKFNMYRLYFGSSYESELGNGTSSDLSSQCLSAPSSMTQDLPGVPGKDQLFSQPPVLRTASQEGCQELTQEQRDQLRADISIIKGRYRSQSGEDESMNQPGPIKTRLAISQSHLMTALGHTRPSISEDDWKNFAELYESFQNPKRRKNQSGTMFRPGQKVTLA

PTMs - O43933 As Substrate

Site PTM Type Enzyme
K191 Ubiquitination
K198 Ubiquitination
Y202 Phosphorylation
K211 Ubiquitination
K260 Ubiquitination
S264 Phosphorylation
K274 Ubiquitination
S278 Phosphorylation
K279 Ubiquitination
K291 Ubiquitination
K337 Ubiquitination
K342 Ubiquitination
K349 Ubiquitination
S354 Phosphorylation
K357 Ubiquitination
K402 Ubiquitination
K411 Ubiquitination
T438 Phosphorylation
K446 Ubiquitination
K455 Ubiquitination
K513 Ubiquitination
S541 Phosphorylation
S585 Phosphorylation
K610 Ubiquitination
K614 Ubiquitination
K619 Ubiquitination
K630 Ubiquitination
K756 Ubiquitination
K763 Ubiquitination
K774 Ubiquitination
K806 Ubiquitination
T810 Phosphorylation
T811 Phosphorylation
K816 Ubiquitination
K833 Ubiquitination
K841 Ubiquitination
Y880 Phosphorylation
T885 Phosphorylation
K887 Ubiquitination
K906 Ubiquitination
K913 Ubiquitination
K933 Ubiquitination
K1001 Ubiquitination
S1172 Phosphorylation
T1179 Phosphorylation
S1181 Phosphorylation
S1201 Phosphorylation
K1204 Ubiquitination
Y1207 Phosphorylation
S1209 Phosphorylation
S1211 Phosphorylation
S1216 Phosphorylation
K1224 Ubiquitination
S1259 Phosphorylation
K1264 Ubiquitination
S1270 Phosphorylation

Research Backgrounds

Function:

Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.

Subcellular Location:

Cytoplasm. Peroxisome membrane.
Note: Associated with peroxisomal membranes.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts directly with PEX6. Interacts indirectly with PEX26, via its interaction with PEX6.

Family&Domains:

Belongs to the AAA ATPase family.

Research Fields

· Cellular Processes > Transport and catabolism > Peroxisome.   (View pathway)

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.