SERPINB3 Antibody - #DF7335

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Product: SERPINB3 Antibody
Catalog: DF7335
Description: Rabbit polyclonal antibody to SERPINB3
Application: WB IHC
Reactivity: Human, Rat
Mol.Wt.: 44kDa; 45kD(Calculated).
Uniprot: P29508
RRID: AB_2839273

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Rat
Clonality:
Polyclonal
Specificity:
SERPINB3 Antibody detects endogenous levels of total SERPINB3.
RRID:
AB_2839273
Cite Format: Affinity Biosciences Cat# DF7335, RRID:AB_2839273.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

HsT1196; Protein T4 A; Protein T4-A; SCC; SCCA; SCCA PD; SCCA-1; SCCA-PD; SCCA1; SCCAPD; Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 3; Serpin B3; Serpin peptidase inhibitor clade B (ovalbumin) member 3; serpin peptidase inhibitor, clade B (ovalbumin), member 3; SERPINB3; SPB3_HUMAN; Squamous cell carcinoma antigen 1; T4 A; T4-A; T4A;

Immunogens

Immunogen:
Uniprot:

P29508(SPB3_HUMAN) >>Visit HPA database.

Gene(ID):
SERPINB3(6317)
Expression:
P29508 SPB3_HUMAN:

Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).

Sequence:
MNSLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQVTENTTGKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGSSPTSTNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP

PTMs - P29508 As Substrate

Site PTM Type Enzyme
T35 Phosphorylation
Y73 Phosphorylation
Y119 Phosphorylation
T129 Phosphorylation
S149 Phosphorylation
S153 Phosphorylation
Y181 Phosphorylation
T206 Phosphorylation
K208 Acetylation
Y216 Phosphorylation
Y384 Phosphorylation

Research Backgrounds

Function:

May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).

Subcellular Location:

Cytoplasm.
Note: Seems to also be secreted in plasma by cancerous cells but at a low level.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).

Subunit Structure:

Interacts with MAPK8/JNK1.

Family&Domains:

Belongs to the serpin family. Ov-serpin subfamily.

Research Fields

· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.

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