LTA4H Antibody - #DF6971

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Product: LTA4H Antibody
Catalog: DF6971
Description: Rabbit polyclonal antibody to LTA4H
Application: WB IHC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Mol.Wt.: 69kDa; 69kD(Calculated).
Uniprot: P09960
RRID: AB_2838927

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(86%), Bovine(86%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(86%)
Clonality:
Polyclonal
Specificity:
LTA4H Antibody detects endogenous levels of total LTA4H.
RRID:
AB_2838927
Cite Format: Affinity Biosciences Cat# DF6971, RRID:AB_2838927.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

FLJ17564; Leukotriene A(4) hydrolase; Leukotriene A-4 hydrolase; Leukotriene A4 hydrolase; LKHA4_HUMAN; LTA-4 hydrolase; LTA4; LTA4 hydrolase; LTA4H;

Immunogens

Immunogen:
Uniprot:

P09960(LKHA4_HUMAN) >>Visit HPA database.

Gene(ID):
LTA4H(4048)
Expression:
P09960 LKHA4_HUMAN:

Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.

Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
100
Sheep
100
Dog
100
Rabbit
100
Pig
86
Bovine
86
Chicken
86
Zebrafish
71
Xenopus
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P09960 As Substrate

Site PTM Type Enzyme
S12 Phosphorylation
S15 Phosphorylation
K20 Ubiquitination
S27 Phosphorylation
T34 Phosphorylation
K58 Acetylation
K58 Ubiquitination
K64 Ubiquitination
K73 Acetylation
K73 Ubiquitination
S81 Phosphorylation
K83 Ubiquitination
S90 Phosphorylation
S96 Phosphorylation
K127 Ubiquitination
C147 S-Nitrosylation
K154 Ubiquitination
S172 Phosphorylation
S186 Phosphorylation
K191 Ubiquitination
S212 Phosphorylation
K225 Ubiquitination
K230 Ubiquitination
S236 Phosphorylation
T238 Phosphorylation
K337 Acetylation
K337 Ubiquitination
K355 Ubiquitination
K365 Ubiquitination
K414 Acetylation
K414 Ubiquitination
S416 Phosphorylation
Y417 Phosphorylation
K418 Acetylation
K418 Ubiquitination
Y430 Phosphorylation
K434 Acetylation
K434 Ubiquitination
K480 Acetylation
K480 Ubiquitination
K493 Ubiquitination
K519 Ubiquitination
K557 Ubiquitination
K566 Ubiquitination
K573 Acetylation
K573 Ubiquitination
K580 Ubiquitination
K593 Ubiquitination
T600 Phosphorylation
K606 Ubiquitination

Research Backgrounds

Function:

Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.

PTMs:

Phosphorylation at Ser-416 inhibits enzymatic activity.

Subcellular Location:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.

Subunit Structure:

Monomer.

Family&Domains:

Belongs to the peptidase M1 family.

Research Fields

· Metabolism > Lipid metabolism > Arachidonic acid metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

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