HMBS Antibody - #DF6611
| Product: | HMBS Antibody |
| Catalog: | DF6611 |
| Description: | Rabbit polyclonal antibody to HMBS |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 39kDa; 39kD(Calculated). |
| Uniprot: | P08397 |
| RRID: | AB_2838573 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF6611, RRID:AB_2838573.
Fold/Unfold
HEM3_HUMAN; HMBS; Hydroxymethylbilane synthase; PBG D; PBG-D; PBGD; PORC; Porphobilinogen deaminase; porphyria, acute; Chester type; Pre uroporphyrinogen synthase; Pre-uroporphyrinogen synthase; UPS; Uroporphyrinogen I synthase; Uroporphyrinogen I synthetase;
Immunogens
- P08397 HEM3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGNGNAAATAEENSPKMRVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGITARNIPRGPQLAAQNLGISLANLLLSKGAKNILDVARQLNDAH
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P08397 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| K17 | Acetylation | Uniprot | |
| S69 | Phosphorylation | Uniprot | |
| K70 | Ubiquitination | Uniprot | |
| K74 | Acetylation | Uniprot | |
| K74 | Ubiquitination | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| K87 | Acetylation | Uniprot | |
| C114 | S-Nitrosylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| K128 | Ubiquitination | Uniprot | |
| K132 | Ubiquitination | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| K157 | Ubiquitination | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| C261 | S-Nitrosylation | Uniprot | |
| S262 | Phosphorylation | Uniprot | |
| T269 | Phosphorylation | Uniprot | |
| K345 | Ubiquitination | Uniprot | |
| K348 | Ubiquitination | Uniprot |
Research Backgrounds
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Cytoplasm.
Isoform 1 is ubiquitously expressed. Isoform 2 is found only in erythroid cells.
Belongs to the HMBS family.
Research Fields
· Metabolism > Metabolism of cofactors and vitamins > Porphyrin and chlorophyll metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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