ARSA Antibody - #DF6584
| Product: | ARSA Antibody |
| Catalog: | DF6584 |
| Description: | Rabbit polyclonal antibody to ARSA |
| Application: | WB IHC IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| Mol.Wt.: | 54kDa; 54kD(Calculated). |
| Uniprot: | P15289 |
| RRID: | AB_2838546 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF6584, RRID:AB_2838546.
Fold/Unfold
arsA; ARSA_HUMAN; arylsulfatase A; Arylsulfatase A component C; As 2; AS A; As2; ASA; AW212749; C230037L18Rik; Cerebroside-sulfatase; metachromatic leucodystrophy; MGC125207; MLD; OTTHUMP00000196546; OTTHUMP00000196548; TISP73;
Immunogens
- P15289 ARSA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGAPRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCPDPHA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P15289 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N158 | N-Glycosylation | Uniprot | |
| N184 | N-Glycosylation | Uniprot | |
| R291 | Methylation | Uniprot | |
| N350 | N-Glycosylation | Uniprot |
Research Backgrounds
Hydrolyzes cerebroside sulfate.
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. This post-translational modification is severely defective in multiple sulfatase deficiency (MSD).
Endoplasmic reticulum. Lysosome.
Homodimer at neutral pH and homooctamer at acidic pH. Exists both as a single chain of 58 kDa (component A) or as a chain of 50 kDa (component B) linked by disulfide bond(s) to a 7 kDa chain (component C). Interacts with SUMF1.
Belongs to the sulfatase family.
Research Fields
· Cellular Processes > Transport and catabolism > Lysosome. (View pathway)
· Metabolism > Lipid metabolism > Sphingolipid metabolism.
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