KIR2DL3 Antibody - #DF6561

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Product: KIR2DL3 Antibody
Catalog: DF6561
Description: Rabbit polyclonal antibody to KIR2DL3
Application: WB IF/ICC
Reactivity: Human
Mol.Wt.: 38kDa; 38kD(Calculated).
Uniprot: P43628
RRID: AB_2838523

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
KIR2DL3 Antibody detects endogenous levels of total KIR2DL3.
RRID:
AB_2838523
Cite Format: Affinity Biosciences Cat# DF6561, RRID:AB_2838523.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

CD158 antigen like family member B2; CD158 antigen-like family member B2; CD158b; CD158b2; GL183; KI2L3_HUMAN; Killer cell immunoglobulin like receptor two domains long cytoplasmic tail 3; Killer cell immunoglobulin-like receptor 2DL3; Killer inhibitory receptor cl 2-3; Killer inhibitory receptor CL2 3; KIR 023GB; KIR-023GB; KIR-K7b; KIR-K7c; KIR023GB; KIR2DL3; KIR2DS5; KIRCL23; MHC class I NK cell receptor; Natural killer associated transcript 2; Natural killer cell inhibitory receptor KIR2DL3; Natural killer-associated transcript 2; NKAT; NKAT-2; NKAT2; NKAT2a; NKAT2b; p58; p58 natural killer cell receptor clone CL 6; p58 natural killer cell receptor clone CL-6; p58 NK Receptor; p58 NK receptor CL 6; p58 NK receptor CL-6; p58.2 MHC class I specific NK receptor; p58.2 MHC class-I-specific NK receptor;

Immunogens

Immunogen:
Uniprot:

P43628(KI2L3_HUMAN) >>Visit HPA database.

Gene(ID):
KIR2DL3(3804)
Description:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Sequence:
MSLMVVSMVCVGFFLLQGAWPHEGVHRKPSLLAHPGPLVKSEETVILQCWSDVRFQHFLLHREGKFKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHERRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVTGNPSNSWPSPTEPSSETGNPRHLHVLIGTSVVIILFILLLFFLLHRWCCNKKNAVVMDQEPAGNRTVNREDSDEQDPQEVTYAQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAEP

PTMs - P43628 As Substrate

Site PTM Type Enzyme
S41 Phosphorylation
T44 Phosphorylation
S51 Phosphorylation
S86 Phosphorylation
Y98 Phosphorylation
T180 Phosphorylation

Research Backgrounds

Function:

Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.

Subcellular Location:

Cell membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with ARRB2.

Family&Domains:

Belongs to the immunoglobulin superfamily.

Research Fields

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Human Diseases > Immune diseases > Graft-versus-host disease.

· Organismal Systems > Immune system > Antigen processing and presentation.   (View pathway)

· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity.   (View pathway)

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For Research Use Only.
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