CD38 Antibody - #DF6551

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Product: CD38 Antibody
Catalog: DF6551
Description: Rabbit polyclonal antibody to CD38
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Rabbit, Chicken
Mol.Wt.: 34kDa; 34kD(Calculated).
Uniprot: P28907
RRID: AB_2838513

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Lead Time: Same day delivery

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Rabbit(100%), Chicken(86%)
Clonality:
Polyclonal
Specificity:
CD38 Antibody detects endogenous levels of total CD38.
RRID:
AB_2838513
Cite Format: Affinity Biosciences Cat# DF6551, RRID:AB_2838513.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

Acute lymphoblastic leukemia cells antigen CD38; ADP ribosyl cyclase 1; ADP ribosyl cyclase; ADP ribosyl cyclase/cyclic ADP-ribose hydrolase; ADP-ribosyl cyclase 1; ADPRC 1; ADPRC1; cADPr hydrolase 1; CD 38; CD38; CD38 antigen (p45); CD38 antigen; CD38 molecule; Cd38-rs1; CD38_HUMAN; CD38H; Cyclic ADP ribose hydrolase; Cyclic ADP ribose hydrolase 1; Cyclic ADP-ribose hydrolase 1; EC 3.2.2.5; Ecto nicotinamide adenine dinucleotide glycohydrolase; I-19; I19 (mouse); Lymphocyte differentiation antigen CD38; NAD(+) nucleosidase; NIM-R5 antigen; NIMR5 antigen (mouse); OTTHUMP00000158633; OTTHUMP00000217743; p45; T10;

Immunogens

Immunogen:
Uniprot:

P28907(CD38_HUMAN) >>Visit HPA database.

Gene(ID):
CD38(952)
Expression:
P28907 CD38_HUMAN:

Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

Description:
CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling.
Sequence:
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Chicken
86
Pig
0
Horse
0
Bovine
0
Sheep
0
Dog
0
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P28907 As Substrate

Site PTM Type Enzyme
K13 Ubiquitination
N100 N-Glycosylation
N209 N-Glycosylation
N219 N-Glycosylation
T258 Phosphorylation

Research Backgrounds

Function:

Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Subcellular Location:

Membrane>Single-pass type II membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

Family&Domains:

Belongs to the ADP-ribosyl cyclase family.

Research Fields

· Environmental Information Processing > Signal transduction > Calcium signaling pathway.   (View pathway)

· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.

· Metabolism > Metabolism of cofactors and vitamins > Nicotinate and nicotinamide metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Immune system > Hematopoietic cell lineage.   (View pathway)

· Organismal Systems > Endocrine system > Oxytocin signaling pathway.

· Organismal Systems > Digestive system > Salivary secretion.

· Organismal Systems > Digestive system > Pancreatic secretion.

References

1). SIRT1 suppresses pituitary tumor progression by downregulating PTTG1 expression. ONCOLOGY REPORTS (PubMed: 35730625) [IF=4.2]

Application: IHC    Species: Human    Sample:

Figure 3. - SIRT1 regulates PTTG1 expression. (A) Bar plot revealing the relative mRNA expression (left panel). *P

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