CBS Antibody - #DF6410
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| Product: | CBS Antibody |
| Catalog: | DF6410 |
| Description: | Rabbit polyclonal antibody to CBS |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Bovine, Sheep, Rabbit, Xenopus |
| Mol.Wt.: | 61kDa; 61kD(Calculated). |
| Uniprot: | P35520 |
| RRID: | AB_2838373 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF6410, RRID:AB_2838373.
Fold/Unfold
AI047524; AI303044; Beta thionase; Beta-thionase; Cbs; Cbs cystathionine beta-synthase; CBS_HUMAN; Cystathionine beta synthase; Cystathionine beta-synthase; EC 4.2.1.22; HIP 4; HIP4; Methylcysteine synthase; MGC18856; MGC18895; MGC37300; OTTHUMP00000109416; OTTHUMP00000109418; Serine sulfhydrase;
Immunogens
In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney.
- P35520 CBS_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTWQLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLLNFVAAQERDQK
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P35520 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T5 | Phosphorylation | Uniprot | |
| C15 | S-Nitrosylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| K72 | Ubiquitination | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| K83 | Ubiquitination | Uniprot | |
| T87 | Phosphorylation | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| C109 | S-Nitrosylation | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| K177 | Ubiquitination | Uniprot | |
| R190 | Methylation | Uniprot | |
| T191 | Phosphorylation | Uniprot | |
| T193 | Phosphorylation | Uniprot | |
| S199 | Phosphorylation | Uniprot | |
| K211 | Sumoylation | Uniprot | |
| K211 | Ubiquitination | Uniprot | |
| S227 | Phosphorylation | Q13976 (PRKG1) | Uniprot |
| S254 | Phosphorylation | Uniprot | |
| T257 | Phosphorylation | Uniprot | |
| T262 | Phosphorylation | Uniprot | |
| K322 | Ubiquitination | Uniprot | |
| K325 | Ubiquitination | Uniprot | |
| R336 | Methylation | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| R389 | Methylation | Uniprot | |
| K394 | Ubiquitination | Uniprot | |
| K398 | Sumoylation | Uniprot | |
| K398 | Ubiquitination | Uniprot | |
| K481 | Acetylation | Uniprot | |
| K481 | Ubiquitination | Uniprot | |
| K485 | Ubiquitination | Uniprot | |
| S525 | Phosphorylation | Q13976 (PRKG1) | Uniprot |
Research Backgrounds
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).
Cytoplasm. Nucleus.
In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney.
Homotetramer.
Belongs to the cysteine synthase/cystathionine beta-synthase family.
Research Fields
· Metabolism > Amino acid metabolism > Glycine, serine and threonine metabolism.
· Metabolism > Amino acid metabolism > Cysteine and methionine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Biosynthesis of amino acids.
References
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