CETP Antibody - #DF6394

(3)  
Product: CETP Antibody
Catalog: DF6394
Description: Rabbit polyclonal antibody to CETP
Application: WB IHC IF/ICC
Reactivity: Human, Mouse
Mol.Wt.: 55kDa; 55kD(Calculated).
Uniprot: P11597
RRID: AB_2838357

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Clonality:
Polyclonal
Specificity:
CETP Antibody detects endogenous levels of total CETP.
RRID:
AB_2838357
Cite Format: Affinity Biosciences Cat# DF6394, RRID:AB_2838357.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

BPIFF; CETP; CETP_HUMAN; Cholesteryl ester transfer protein; Cholesteryl ester transfer protein plasma; HDLCQ10; Lipid transfer protein I;

Immunogens

Immunogen:
Uniprot:

P11597(CETP_HUMAN) >>Visit HPA database.

Gene(ID):
CETP(1071)
Expression:
P11597 CETP_HUMAN:

Expressed by the liver and secreted in plasma.

Description:
Cholesteryl ester transfer protein (CETP) is a circulating metabolic enzyme that transports cholesterol from the arteries to the liver (1-3). CETP converts cholesteryl esters from antiatherogenic high density lipoproteins (HDLs) to proatherogenicapolipoprotein B (apoB)-containing lipoproteins, including very low-, intermediate-, and low-DLs (3). Efficient transfer and exchange of cholesteryl esters and triglycerides between the lipoprotein classes of human plasma is necessary to maintain healthy arteries (4,5).
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS

PTMs - P11597 As Substrate

Site PTM Type Enzyme
N105 N-Glycosylation
T113 Phosphorylation
N257 N-Glycosylation
S349 Phosphorylation
N358 N-Glycosylation
S400 Phosphorylation
T407 Phosphorylation

Research Backgrounds

Function:

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination.

Subcellular Location:

Secreted>Extracellular space.
Note: Secreted in plasma.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed by the liver and secreted in plasma.

Family&Domains:

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Research Fields

· Organismal Systems > Digestive system > Cholesterol metabolism.

Restrictive clause

 

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