LYZL6 Antibody - #DF6212

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Product: LYZL6 Antibody
Catalog: DF6212
Description: Rabbit polyclonal antibody to LYZL6
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Mol.Wt.: 17kDa; 17kD(Calculated).
Uniprot: O75951
RRID: AB_2838178

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Clonality:
Polyclonal
Specificity:
LYZL6 Antibody detects endogenous levels of total LYZL6.
RRID:
AB_2838178
Cite Format: Affinity Biosciences Cat# DF6212, RRID:AB_2838178.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

EC 3.2.1.17; LYC1; Lysozyme homolog; Lysozyme like 6; UNQ754/PRO1485;

Immunogens

Immunogen:
Uniprot:

O75951(LYZL6_HUMAN) >>Visit HPA database.

Gene(ID):
LYZL6(57151)
Expression:
O75951 LYZL6_HUMAN:

Expressed in testis, epididymis and spermatozoa (at protein level) (PubMed:16014814, PubMed:28182716). Expressed in late-stage spermatocytes and round spermatids (PubMed:28182716).

Description:
This gene encodes a member of the C-type lysozyme/alpha-lactalbumin family. C-type lysozymes are bacteriolytic factors that play a role in host defense, whereas alpha-lactalbumins mediate lactose biosynthesis. The encoded protein contains catalytic residues characteristic of C-type lysozymes and may play a role in male reproduction. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
Sequence:
MTKALLIYLVSSFLALNQASLISRCDLAQVLQLEDLDGFEGYSLSDWLCLAFVESKFNISKINENADGSFDYGLFQINSHYWCNDYKSYSENLCHVDCQDLLNPNLLAGIHCAKRIVSGARGMNNWVEWRLHCSGRPLFYWLTGCRLR

PTMs - O75951 As Substrate

Site PTM Type Enzyme
S134 Phosphorylation
Y140 Phosphorylation

Research Backgrounds

Function:

May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6.

Subcellular Location:

Secreted. Cell surface. Cell projection>Cilium>Flagellum.
Note: Detected on the postacrosomal membrane of mature spermatozoa (PubMed:28182716).

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed in testis, epididymis and spermatozoa (at protein level). Expressed in late-stage spermatocytes and round spermatids.

Subunit Structure:

Monomer.

Family&Domains:

Belongs to the glycosyl hydrolase 22 family.

Restrictive clause

 

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