PPP1R2 Antibody - #AF5455
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# AF5455, RRID:AB_2837939.
Fold/Unfold
IPP 2; IPP-2; IPP2; IPP2_HUMAN; MGC87148; Phosphatase inhibitor 2; Phosphoprotein phosphatase; Ppp1r2; PPP1R2 protein; Protein phosphatase 1 regulatory (inhibitor) subunit 2; Protein phosphatase 1 regulatory subunit 2; Protein phosphatase inhibitor 2;
Immunogens
- P41236 IPP2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAASTASHRPIKGILKNKTSTTSSMVASAEQPRGNVDEELSKKSQKWDEMNILATYHPADKDYGLMKIDEPSTPYHSMMGDDEDACSDTEATEAMAPDILARKLAAAEGLEPKYRIQEQESSGEEDSDLSPEEREKKRQFEMKRKLHYNEGLNIKLARQLISKDLHDDDEDEEMLETADGESMNTEESNQGSTPSDQQQNKLRSS
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P41236 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S4 | Phosphorylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| T19 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| S23 | Phosphorylation | Uniprot | |
| S24 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| R33 | Methylation | Uniprot | |
| S44 | Phosphorylation | Q13315 (ATM) | Uniprot |
| T55 | Phosphorylation | Uniprot | |
| Y56 | Phosphorylation | Uniprot | |
| Y63 | Phosphorylation | Uniprot | |
| S72 | Phosphorylation | P27448 (MARK3) | Uniprot |
| T73 | Phosphorylation | P49841 (GSK3B) , Q00535 (CDK5) | Uniprot |
| Y75 | Phosphorylation | Uniprot | |
| S77 | Phosphorylation | Uniprot | |
| S87 | Phosphorylation | P68400 (CSNK2A1) , P19784 (CSNK2A2) , O94921 (CDK14) | Uniprot |
| T89 | Phosphorylation | Uniprot | |
| T92 | Phosphorylation | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| K113 | Ubiquitination | Uniprot | |
| Y114 | Phosphorylation | Uniprot | |
| S121 | Phosphorylation | P68400 (CSNK2A1) , P19784 (CSNK2A2) | Uniprot |
| S122 | Phosphorylation | P68400 (CSNK2A1) , P19784 (CSNK2A2) | Uniprot |
| S127 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| K145 | Ubiquitination | Uniprot | |
| Y148 | Phosphorylation | Uniprot | |
| K155 | Ubiquitination | Uniprot | |
| T193 | Phosphorylation | Uniprot |
Research Backgrounds
Inhibitor of protein-phosphatase 1.
Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.
Heterodimer with PP1.
Belongs to the protein phosphatase inhibitor 2 family.
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