BMP6 Antibody - #AF5196

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Product: BMP6 Antibody
Catalog: AF5196
Description: Rabbit polyclonal antibody to BMP6
Application: WB IHC
Reactivity: Human
Mol.Wt.: 57 kDa; 57kD(Calculated).
Uniprot: P22004
RRID: AB_2837682

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
BMP6 Antibody detects endogenous levels of total BMP6.
RRID:
AB_2837682
Cite Format: Affinity Biosciences Cat# AF5196, RRID:AB_2837682.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

BMP-6; Bmp6; BMP6_HUMAN; Bone morphogenetic protein 6; Bone Morphogenic Protein 6; Decapentaplegic vegetal related; DVR6; HGNC:12686; TGFB related vegetal related growth factor; Transforming growth factor beta; Vegetal related (TGFB related) cytokine; Vegetal related growth factor (TGFB related); Vg related sequence; VG-1-R; VG-1-related protein; Vg1 related sequence; VGR; VGR-1; VGR1;

Immunogens

Immunogen:
Uniprot:

P22004(BMP6_HUMAN) >>Visit HPA database.

Gene(ID):
BMP6(654)
Description:
Induces cartilage and bone formation.
Sequence:
MPGLGRRAQWLCWWWGLLCSCCGPPPLRPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH

PTMs - P22004 As Substrate

Site PTM Type Enzyme
S398 O-Glycosylation

Research Backgrounds

Function:

Induces cartilage and bone formation.

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Subunit Structure:

Interacts with SOSTDC1.

Family&Domains:

Belongs to the TGF-beta family.

Research Fields

· Environmental Information Processing > Signal transduction > TGF-beta signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Hippo signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Ovarian steroidogenesis.

References

1). A novel UV-curable extravascular stent to prevent restenosis of venous grafts. Composites Part B: Engineering [IF=13.1]
2). TNIK drives castration-resistant prostate cancer via phosphorylating EGFR. iScience (PubMed: 38226156) [IF=5.8]
3). H2O2 induces oxidative stress damage through the BMP‐6/SMAD/hepcidin axis. DEVELOPMENT GROWTH & DIFFERENTIATION (PubMed: 32012242) [IF=2.5]

Application: WB    Species: human    Sample: retinal pigment epithelial (RPE) cells

FIGURE 2|Effect of oxidative stress on BMP-6 mRNA and protein levels in retinal pigment epithelial (RPE) cells. (a) Compared with that in the blank control group, the level of BMP-6 mRNA in the H2O2-treated group decreased significantly, *p < .05. (b) Western blot images of BMP-6.

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