P2RY4 Antibody - #DF5136
| Product: | P2RY4 Antibody |
| Catalog: | DF5136 |
| Description: | Rabbit polyclonal antibody to P2RY4 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Pig |
| Mol.Wt.: | 41 KD; 41kD(Calculated). |
| Uniprot: | P51582 |
| RRID: | AB_2837495 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF5136, RRID:AB_2837495.
Fold/Unfold
NRU; Nucleotide receptor uridine; P2P; P2ry4; P2RY4_HUMAN; P2Y purinoceptor 4; P2Y4; P2Y4R; Pyrimidinergic receptor P2Y G protein coupled 4; UNR; Uridine nucleotide receptor;
Immunogens
- P51582 P2RY4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTSNKGTTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEADCRVLNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTPRADRL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P51582 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S237 | Phosphorylation | Uniprot | |
| S333 | Phosphorylation | Uniprot | |
| S334 | Phosphorylation | Uniprot | |
| S358 | Phosphorylation | Uniprot |
Research Backgrounds
Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.
Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.
Cell membrane>Multi-pass membrane protein.
Pancreas.
Belongs to the G-protein coupled receptor 1 family.
Research Fields
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Organismal Systems > Sensory system > Taste transduction.
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