OPRD1 Antibody - #DF5043
| Product: | OPRD1 Antibody |
| Catalog: | DF5043 |
| Description: | Rabbit polyclonal antibody to OPRD1 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Bovine, Rabbit |
| Mol.Wt.: | 36 KD; 40kD(Calculated). |
| Uniprot: | P41143 |
| RRID: | AB_2837402 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF5043, RRID:AB_2837402.
Fold/Unfold
D-OR-1; Delta type opioid receptor; Delta type opioid receptor DOR 1; Delta type opioid receptor DOR1; Delta-type opioid receptor; DOR 1; DOR-1; DOR1; mDOR; Nbor; Opioid receptor delta 1; OPRD 1; OPRD; OPRD_HUMAN; Oprd1;
Immunogens
Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.
- P41143 OPRD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P41143 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T161 | Phosphorylation | Q00535 (CDK5) | Uniprot |
| T211 | Phosphorylation | Uniprot | |
| T213 | Phosphorylation | Uniprot | |
| S344 | Phosphorylation | Q05655 (PRKCD) , Q02156 (PRKCE) , P17252 (PRKCA) | Uniprot |
| T358 | Phosphorylation | P25098 (GRK2) , A0A0S2Z3I6 (ADRBK1) | Uniprot |
| T361 | Phosphorylation | A0A0S2Z3I6 (ADRBK1) | Uniprot |
| S363 | Phosphorylation | P25098 (GRK2) , A0A0S2Z3I6 (ADRBK1) | Uniprot |
Research Backgrounds
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
N-glycosylated.
Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.
Cell membrane>Multi-pass membrane protein.
Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.
May form homooligomers. Forms a heterodimer with OPRM1 (By similarity). Interacts with GPRASP1. Interacts with RTP4; the interaction promotes cell surface localization of the OPRD1-OPRM1 heterodimer (By similarity).
Belongs to the G-protein coupled receptor 1 family.
Research Fields
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.