Product: MTLR Antibody
Catalog: DF4993
Description: Rabbit polyclonal antibody to MTLR
Application: WB IF/ICC
Reactivity: Human
Mol.Wt.: 45 KD; 45kD(Calculated).
Uniprot: O43193
RRID: AB_2837352

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 100ul $280 In stock
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Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human
Clonality:
Polyclonal
Specificity:
MTLR Antibody detects endogenous levels of total MTLR.
RRID:
AB_2837352
Cite Format: Affinity Biosciences Cat# DF4993, RRID:AB_2837352.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

G-protein coupled receptor 38; GPR38; MLNR; Motilin receptor; MTLR; MTLR_HUMAN; MTLR1;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Expression:
O43193 MTLR_HUMAN:

Expressed only in thyroid, stomach, and bone marrow.

Sequence:
MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG

PTMs - O43193 As Substrate

Site PTM Type Enzyme
T71 Phosphorylation
T72 Phosphorylation
T73 Phosphorylation
S83 Phosphorylation
R136 Methylation
T296 Phosphorylation
T324 Phosphorylation
S327 Phosphorylation
T402 Phosphorylation
T404 Phosphorylation

Research Backgrounds

Function:

Receptor for motilin.

Subcellular Location:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Expressed only in thyroid, stomach, and bone marrow.

Family&Domains:

Belongs to the G-protein coupled receptor 1 family.

Research Fields

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

References

1). Motilin and its receptor are expressed in the dorsal horn in a rat model of acute incisional pain: Intrathecal motilin injection alleviates pain behaviors. Frontiers in Neuroscience, 2023 (PubMed: 36816129) [IF=4.3]

Application: IF/ICC    Species: Rat    Sample: spinal cord

FIGURE 2 (A) Motilin (MTL) and MTL receptor (MTLR) fluorescence co-labeling in the spinal dorsal horn 2 h after acute incisional pain. (B) Co-labeling of MTLR and β-tubulin III fluorescence in the spinal dorsal horn. MTL (red), MTLR (green), β-tubulin III (violet), and DAPI (blue). Scale bar = 100 μm/20 μm.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.