GPRC6A Antibody - #DF4964
| Product: | GPRC6A Antibody |
| Catalog: | DF4964 |
| Description: | Rabbit polyclonal antibody to GPRC6A |
| Application: | WB IF/ICC |
| Reactivity: | Human |
| Prediction: | Pig, Bovine, Horse, Rabbit, Dog, Chicken |
| Mol.Wt.: | 105 KD; 105kD(Calculated). |
| Uniprot: | Q5T6X5 |
| RRID: | AB_2837317 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4964, RRID:AB_2837317.
Fold/Unfold
bA86F4.3; G protein coupled receptor 33; G protein coupled receptor family C group 6 member A; G-protein coupled receptor family C group 6 member A; G-protein coupled receptor GPCR33; GPC6A_HUMAN; GPCR 33; GPCR 6A; GPCR; GPCR33; GPR C6A; GPRC 6A; gprc6a; hGPCR 33; hGPCR33; hGPRC6A; OTTHUMP00000017075; Predicted with SOSUI analysis; seven transmembrane helix receptor;
Immunogens
Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues.
- Q5T6X5 GPC6A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQAQAFAHICRENATSVSKTLPRKRMSSI
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q5T6X5 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T107 | Phosphorylation | Uniprot | |
| N121 | N-Glycosylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| N259 | N-Glycosylation | Uniprot | |
| T261 | Phosphorylation | Uniprot | |
| T312 | Phosphorylation | Uniprot | |
| T313 | Phosphorylation | Uniprot | |
| N332 | N-Glycosylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| S350 | Phosphorylation | Uniprot | |
| N378 | N-Glycosylation | Uniprot | |
| N452 | N-Glycosylation | Uniprot | |
| N555 | N-Glycosylation | Uniprot | |
| N567 | N-Glycosylation | Uniprot | |
| T621 | Phosphorylation | Uniprot | |
| S626 | Phosphorylation | Uniprot | |
| S627 | Phosphorylation | Uniprot | |
| Y778 | Phosphorylation | Uniprot | |
| S886 | Phosphorylation | Uniprot |
Research Backgrounds
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.
N-glycosylated.
Cell membrane>Multi-pass membrane protein.
Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues.
Homodimer; disulfide-linked.
Belongs to the G-protein coupled receptor 3 family.
Research Fields
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
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