MC2R Antibody - #DF4909

(2)  
Product: MC2R Antibody
Catalog: DF4909
Description: Rabbit polyclonal antibody to MC2R
Application: WB IF/ICC
Reactivity: Human, Mouse
Prediction: Bovine, Horse, Sheep, Dog
Mol.Wt.: 34 KD; 34kD(Calculated).
Uniprot: Q01718
RRID: AB_2837262

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 100ul $280 In stock
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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Bovine(89%), Horse(89%), Sheep(89%), Dog(89%)
Clonality:
Polyclonal
Specificity:
MC2R Antibody detects endogenous levels of total MC2R.
RRID:
AB_2837262
Cite Format: Affinity Biosciences Cat# DF4909, RRID:AB_2837262.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ACTH receptor; ACTH-R; ACTHR; ACTHR_HUMAN; Adrenocorticotropic hormone receptor; Adrenocorticotropin receptor; Corticotropin receptor; MC2 receptor; MC2-R; MC2R; Melanocortin 2 receptor (adrenocorticotropic hormone); Melanocortin 2 receptor; Melanocortin receptor 2;

Immunogens

Immunogen:
Uniprot:

Q01718(ACTHR_HUMAN) >>Visit HPA database.

Gene(ID):
MC2R(4158)
Expression:
Q01718 ACTHR_HUMAN:

Melanocytes and corticoadrenal tissue.

Sequence:
MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Horse
89
Bovine
89
Sheep
89
Dog
89
Rabbit
63
Pig
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q01718 As Substrate

Site PTM Type Enzyme
T143 Phosphorylation
T204 Phosphorylation
S208 Phosphorylation
S280 Phosphorylation

Research Backgrounds

Function:

Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).

Subcellular Location:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Melanocytes and corticoadrenal tissue.

Subunit Structure:

Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).

Family&Domains:

Belongs to the G-protein coupled receptor 1 family.

Research Fields

· Environmental Information Processing > Signal transduction > cAMP signaling pathway.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.

Restrictive clause

 

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