GPR109 Antibody - #DF4890
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Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4890, RRID:AB_2837243.
Fold/Unfold
G protein coupled receptor 109B; G protein coupled receptor HM74; G protein coupled receptor HM74B; G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; GPR109B; HCA3; HCAR3; HCAR3_HUMAN; HM74; HM74B; Hydroxycarboxylic acid receptor 3; Niacin receptor 2; NIACR2; Nicotinic acid receptor 2; Puma g; PUMAG; G protein coupled receptor 109A; G protein coupled receptor HM74a; G protein coupled receptor Hm74b; G-protein coupled receptor 109A; G-protein coupled receptor HM74A; G109A_HUMAN; GPR 109A; Gpr109a; GPR109A protein; HCA2; HCAR2; HM 74; HM 74a; HM 74b; Hm74; HM74a; HM74b; hydroxycarboxylic acid receptor 2; Interferon gamma inducible gene Puma g; Niacin receptor 1; NIACR1; Nicotinic acid receptor 1; Nicotinic acid receptor; Protein upregulated in macrophages by IFNG, mouse, homolog of; Puma g; Pumag; rHM74b;
Immunogens
Expression largely restricted to adipose tissue and spleen.
Q8TDS4 HCAR2_HUMAN:Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.
- P49019 HCAR3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
- Q8TDS4 HCAR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
PTMs - P49019/Q8TDS4 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S328 | Phosphorylation | Uniprot |
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S328 | Phosphorylation | Uniprot |
Research Backgrounds
Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
Cell membrane>Multi-pass membrane protein.
Expression largely restricted to adipose tissue and spleen.
Belongs to the G-protein coupled receptor 1 family.
Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
Cell membrane>Multi-pass membrane protein.
Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.
Belongs to the G-protein coupled receptor 1 family.
Research Fields
· Environmental Information Processing > Signal transduction > cAMP signaling pathway. (View pathway)
References
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