EDG6 Antibody - #DF4872
| Product: | EDG6 Antibody |
| Catalog: | DF4872 |
| Description: | Rabbit polyclonal antibody to EDG6 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse |
| Prediction: | Pig, Bovine, Horse, Sheep, Dog |
| Mol.Wt.: | 40 KD; 42kD(Calculated). |
| Uniprot: | O95977 |
| RRID: | AB_2837235 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4872, RRID:AB_2837235.
Fold/Unfold
EDG6; Endothelial differentiation lysophosphatidic acid G protein coupled receptor 6; Endothelial differentiation G protein coupled receptor 6; Endothelial differentiation G-protein coupled receptor 6; Endothelial differentiation gene 6; LPC1; Lysophospholipid receptor C1; MGC129298; Putative G protein coupled receptor; S1P receptor 4; S1P receptor Edg-6; S1P receptor Edg6; S1P4; S1PR4; S1PR4_HUMAN; SLP4; Sphingosine 1 phosphate receptor 4; Sphingosine 1 phosphate receptor Edg6; Sphingosine 1-phosphate receptor 4; Sphingosine 1-phosphate receptor Edg-6;
Immunogens
Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.
- O95977 S1PR4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95977 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S194 | Phosphorylation | Uniprot | |
| S195 | Phosphorylation | Uniprot | |
| S354 | Phosphorylation | Uniprot | |
| S377 | Phosphorylation | Uniprot | |
| S380 | Phosphorylation | Uniprot | |
| S383 | Phosphorylation | Uniprot |
Research Backgrounds
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.
Cell membrane>Multi-pass membrane protein.
Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.
Belongs to the G-protein coupled receptor 1 family.
Research Fields
· Environmental Information Processing > Signal transduction > FoxO signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
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