FPR1 Antibody - #DF4881
| Product: | FPR1 Antibody |
| Catalog: | DF4881 |
| Description: | Rabbit polyclonal antibody to FPR1 |
| Application: | WB IF/ICC |
| Reactivity: | Human |
| Mol.Wt.: | 40 KD; 38kD(Calculated). |
| Uniprot: | P21462 |
| RRID: | AB_2837173 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4881, RRID:AB_2837173.
Fold/Unfold
fMet Leu Phe receptor; fMet-Leu-Phe receptor; FMLP; fMLP receptor; FMLPR; Formyl peptide receptor 1; FPR 1; FPR; FPR receptor; FPR1; FPR1_HUMAN; N formyl peptide chemoattractant receptor; N formyl peptide receptor; N formylpeptide chemoattractant receptor; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor;
Immunogens
- P21462 FPR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
PTMs - P21462 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y22 | Phosphorylation | Uniprot | |
| S211 | Phosphorylation | Uniprot | |
| S215 | Phosphorylation | Uniprot | |
| S220 | Phosphorylation | Uniprot | |
| T325 | Phosphorylation | Uniprot | |
| S328 | Phosphorylation | A0A0S2Z3I6 (ADRBK1) | Uniprot |
| T329 | Phosphorylation | A0A0S2Z3I6 (ADRBK1) | Uniprot |
| T331 | Phosphorylation | A0A0S2Z3I6 (ADRBK1) | Uniprot |
| S332 | Phosphorylation | A0A0S2Z3I6 (ADRBK1) | Uniprot |
| T334 | Phosphorylation | A0A0S2Z3I6 (ADRBK1) | Uniprot |
| T336 | Phosphorylation | A0A0S2Z3I6 (ADRBK1) | Uniprot |
| S338 | Phosphorylation | A0A0S2Z3I6 (ADRBK1) | Uniprot |
| T339 | Phosphorylation | A0A0S2Z3I6 (ADRBK1) | Uniprot |
| S342 | Phosphorylation | Q16539 (MAPK14) | Uniprot |
Research Backgrounds
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release.
Phosphorylated; which is necessary for desensitization.
Cell membrane>Multi-pass membrane protein.
Note: Internalizes in presence of its ligand, TAFA4.
Neutrophils.
Interacts with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response.
Belongs to the G-protein coupled receptor 1 family.
Research Fields
· Environmental Information Processing > Signal transduction > Rap1 signaling pathway. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
· Human Diseases > Infectious diseases: Bacterial > Staphylococcus aureus infection.
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