SDC1 Antibody - #DF4807
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4807, RRID:AB_2837100.
Fold/Unfold
CD_antigen; CD138; CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor; SDC; Sdc1; SDC1_HUMAN; SYND1; Syndecan 1; syndecan proteoglycan 1; Syndecan-1;
Immunogens
- P18827 SDC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MRRAALWLWLCALALSLQPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P18827 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T61 | O-Glycosylation | Uniprot | |
| T72 | O-Glycosylation | Uniprot | |
| T76 | O-Glycosylation | Uniprot | |
| S77 | O-Glycosylation | Uniprot | |
| T81 | O-Glycosylation | Uniprot | |
| T122 | O-Glycosylation | Uniprot | |
| T164 | O-Glycosylation | Uniprot | |
| S165 | O-Glycosylation | Uniprot | |
| T166 | O-Glycosylation | Uniprot | |
| S171 | O-Glycosylation | Uniprot | |
| T177 | O-Glycosylation | Uniprot | |
| T180 | O-Glycosylation | Uniprot | |
| S186 | O-Glycosylation | Uniprot | |
| T188 | O-Glycosylation | Uniprot | |
| T240 | O-Glycosylation | Uniprot | |
| K280 | Ubiquitination | Uniprot | |
| K281 | Ubiquitination | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| Y286 | Phosphorylation | Uniprot | |
| S287 | Phosphorylation | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| Y299 | Phosphorylation | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| K304 | Ubiquitination | Uniprot | |
| Y309 | Phosphorylation | Uniprot |
Research Backgrounds
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
Membrane>Single-pass type I membrane protein. Secreted. Secreted>Extracellular exosome.
Note: Shedding of the ectodomain produces a soluble form.
Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain). Interacts with MDK (By similarity).
Belongs to the syndecan proteoglycan family.
Research Fields
· Environmental Information Processing > Signaling molecules and interaction > ECM-receptor interaction. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Human Diseases > Infectious diseases: Parasitic > Malaria.
· Human Diseases > Cancers: Overview > Proteoglycans in cancer.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.