CDC14A Antibody - #DF4732
| Product: | CDC14A Antibody |
| Catalog: | DF4732 |
| Description: | Rabbit polyclonal antibody to CDC14A |
| Application: | WB IF/ICC |
| Reactivity: | Human |
| Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| Mol.Wt.: | 66 KD; 67kD(Calculated). |
| Uniprot: | Q9UNH5 |
| RRID: | AB_2837083 |
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4732, RRID:AB_2837083.
Fold/Unfold
CDC 10; Cdc 14; Cdc 14A; Cdc 14A1; Cdc 14A2; CDC10 (cell division cycle 10, S. cerevisiae, homolog); CDC10; Cdc14; CDC14 cell division cycle 14 homolog A; CDC14 homolog A; Cdc14A1; Cdc14A2; Cell division cycle 14 homolog A; Cell division cycle 14, S. cerevisiae, homolog A; Cell division cycle 14A; Dual specificity protein phosphatase CDC 14A; Dual specificity protein phosphatase CDC14A; hCDC 14; hCDC14; OTTHUMP00000012653; OTTHUMP00000012654; OTTHUMP00000012655;
Immunogens
- Q9UNH5 CC14A_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAESGELIGACEFMKDRLYFATLRNRPKSTVNTHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLSSSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPSLQSEYVHY
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UNH5 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K69 | Ubiquitination | Uniprot | |
| K72 | Ubiquitination | Uniprot | |
| Y84 | Phosphorylation | Uniprot | |
| T85 | Phosphorylation | Uniprot | |
| T222 | Phosphorylation | Uniprot | |
| S348 | Phosphorylation | Uniprot | |
| S351 | Phosphorylation | Uniprot | |
| S363 | Phosphorylation | Uniprot | |
| S411 | Phosphorylation | Uniprot | |
| K422 | Methylation | Uniprot | |
| S429 | Phosphorylation | Uniprot | |
| S435 | Phosphorylation | Uniprot | |
| S436 | Phosphorylation | Uniprot | |
| S437 | Phosphorylation | Uniprot | |
| S441 | Phosphorylation | Uniprot | |
| T444 | Phosphorylation | Uniprot | |
| T447 | Phosphorylation | Uniprot | |
| S453 | Phosphorylation | Uniprot | |
| S465 | Phosphorylation | Uniprot | |
| S476 | Phosphorylation | Uniprot | |
| S484 | Phosphorylation | Uniprot | |
| S549 | Phosphorylation | Uniprot | |
| S583 | Phosphorylation | Uniprot | |
| S589 | Phosphorylation | Uniprot | |
| Y591 | Phosphorylation | Uniprot |
Research Backgrounds
Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing.
Nucleus. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm>Cytoskeleton>Spindle pole. Cytoplasm>Cytoskeleton>Spindle. Cell projection>Kinocilium. Cell projection>Stereocilium.
Note: Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the mitotic spindle pole and at the central spindle (PubMed:12134069, PubMed:11901424, PubMed:15263015). Present along both the transient kinocilia of developing cochlear hair cells and the persistent kinocilia of vestibular hair cells (By similarity).
Interacts with KIF20A, which is required to localize CDC14 to the midzone of the mitotic spindle.
Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
Research Fields
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
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