IL18BP Antibody - #DF4709

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Product: IL18BP Antibody
Catalog: DF4709
Description: Rabbit polyclonal antibody to IL18BP
Application: WB IF/ICC
Reactivity: Human, Rat
Mol.Wt.: 44 KD; 21kD(Calculated).
Uniprot: O95998
RRID: AB_2837060

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Rat
Clonality:
Polyclonal
Specificity:
IL18BP Antibody detects endogenous levels of total IL18BP.
RRID:
AB_2837060
Cite Format: Affinity Biosciences Cat# DF4709, RRID:AB_2837060.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

I18BP_HUMAN; IL-18BP; IL18 BP; IL18 BPa; IL18BP; IL18BPa; Interleukin 18 binding protein; Interleukin-18-binding protein; MC51L 53L 54L homolog gene product; Tadekinig alfa; Tadekinig-alfa;

Immunogens

Immunogen:

A synthesized peptide derived from human IL18BP, corresponding to a region within C-terminal amino acids.

Uniprot:

O95998(I18BP_HUMAN) >>Visit HPA database.

Gene(ID):
IL18BP(10068)
Expression:
O95998 I18BP_HUMAN:

Strongly expressed in heart, lung, placenta and spleen.

Sequence:
MTMRHNWTPDLSPLWVLLLCAHVVTLLVRATPVSQTTTAATASVRSTKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLNGTLSLSCVACSRFPNFSILYWLGNGSFIEHLPGRLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRHVVLAQLWAGLRATLPPTQEALPSSHSSPQQQG

PTMs - O95998 As Substrate

Site PTM Type Enzyme
T31 Phosphorylation
S34 Phosphorylation
S46 O-Glycosylation
T47 O-Glycosylation
S53 O-Glycosylation
N103 N-Glycosylation
N147 N-Glycosylation

Research Backgrounds

Function:

Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.

PTMs:

N- and O-glycosylated. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Ser-53: HexHexNAc (major) and Hex2HexNAc2 (minor). N-glycan heterogeneity at Asn-103: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major) and Hex6HexNAc5 (minor); N-glycan at Asn-147: dHex1Hex5HexNAc4.

Subcellular Location:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Strongly expressed in heart, lung, placenta and spleen.

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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