CACNG1 Antibody - #DF4612

(3)  
Product: CACNG1 Antibody
Catalog: DF4612
Description: Rabbit polyclonal antibody to CACNG1
Application: WB IHC IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 25 KD; 25kD(Calculated).
Uniprot: Q06432
RRID: AB_2836976

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(82%), Horse(100%), Rabbit(100%), Dog(91%), Chicken(100%), Xenopus(82%)
Clonality:
Polyclonal
Specificity:
CACNG1 Antibody detects endogenous levels of total CACNG1.
RRID:
AB_2836976
Cite Format: Affinity Biosciences Cat# DF4612, RRID:AB_2836976.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

CACNG1; CACNLG; CACNLG calcium channel neuronal dihydrpyridine sensitive gamma subunit; Calcium channel L type gamma polypeptide; Calcium channel voltage dependent gamma subunit 1; CCG1_HUMAN; Dihydropyridine sensitive L type skeletal muscle calcium channel gamma subunit; Dihydropyridine sensitive L type skeletal muscle calcium channel subunit gamma; Dihydropyridine-sensitive L-type; fb43f02; fi19g08; L type calcium channel gamma polypeptide; MGC117703; skeletal muscle calcium channel subunit gamma; Voltage dependent calcium channel gamma 1 subunit 2; Voltage-dependent calcium channel gamma-1 subunit; wu:fb43f02; zgc:55364;

Immunogens

Immunogen:
Uniprot:

Q06432(CCG1_HUMAN) >>Visit HPA database.

Gene(ID):
CACNG1(786)
Expression:
Q06432 CCG1_HUMAN:

Skeletal muscle.

Sequence:
MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSPHMEHHNTTCEAAHFGLWRICTKRIPMDDSKTCGPITLPGEKNCSYFRHFNPGESSEIFEFTTQKEYSISAAAIAIFSLGFIILGSLCVLLSLGKKRDYLLRPASMFYAFAGLCILVSVEVMRQSVKRMIDSEDTVWIEYYYSWSFACACAAFILLFLGGLALLLFSLPRMPRNPWESCMDAEPEH

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Chicken
100
Rabbit
100
Dog
91
Bovine
82
Xenopus
82
Sheep
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q06432 As Substrate

Site PTM Type Enzyme
Y135 Phosphorylation
S161 Phosphorylation

Research Backgrounds

Function:

Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.

PTMs:

N-glycosylated.

Subcellular Location:

Cell membrane>Sarcolemma>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Skeletal muscle.

Subunit Structure:

Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.

Family&Domains:

Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Research Fields

· Environmental Information Processing > Signal transduction > MAPK signaling pathway.   (View pathway)

· Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).

· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).

· Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).

· Organismal Systems > Circulatory system > Cardiac muscle contraction.   (View pathway)

· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes.   (View pathway)

· Organismal Systems > Endocrine system > Oxytocin signaling pathway.

Restrictive clause

 

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For Research Use Only.
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