VANGL1 Antibody - #DF4607

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Product: VANGL1 Antibody
Catalog: DF4607
Description: Rabbit polyclonal antibody to VANGL1
Application: WB IF/ICC
Reactivity: Human, Mouse
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Mol.Wt.: 50 KD; 60kD(Calculated).
Uniprot: Q8TAA9
RRID: AB_2836971

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(85%)
Clonality:
Polyclonal
Specificity:
VANGL1 Antibody detects endogenous levels of total VANGL1.
RRID:
AB_2836971
Cite Format: Affinity Biosciences Cat# DF4607, RRID:AB_2836971.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

ANGL planar cell polarity protein 1; KAI1 C-terminal interacting tetraspanin; KITENIN; Loop tail protein 2 homolog; Loop-tail protein 2 homolog; LPP2; MGC5338; STB2; STBM2; Strabismus 2; Strabismus, Drosophila, homolog of, 2; Van Gogh like protein 1; Van Gogh, Drosophila, homolog of, 1; Van Gogh-like protein 1; Vang like 1 (van gogh, Drosophila); Vang like protein 1; Vang-like 1; Vang-like protein 1; VANG1_HUMAN; VANGL 1; Vangl1;

Immunogens

Immunogen:
Uniprot:

Q8TAA9(VANG1_HUMAN) >>Visit HPA database.

Gene(ID):
VANGL1(81839)
Expression:
Q8TAA9 VANG1_HUMAN:

According to PubMed:11956595, ubiquitously expressed. According to PubMed:12011995, expressed specifically in testis and ovary.

Sequence:
MDTESTYSGYSYYSSHSKKSHRQGERTRERHKSPRNKDGRGSEKSVTIQPPTGEPLLGNDSTRTEEVQDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTICEGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIVLLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMIAAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHSMESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDPKSHKFVLRLQSETSV

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Chicken
85
Zebrafish
62
Xenopus
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q8TAA9 As Substrate

Site PTM Type Enzyme
Y7 Phosphorylation
Y13 Phosphorylation
S17 Phosphorylation
S20 Phosphorylation
S42 Phosphorylation
K44 Ubiquitination
S45 Phosphorylation
T52 Phosphorylation
S83 Phosphorylation
S86 Phosphorylation
S88 Phosphorylation
S96 Phosphorylation
K97 Ubiquitination
T288 Phosphorylation
Y290 Phosphorylation
T296 Phosphorylation
K299 Ubiquitination
K304 Ubiquitination
K310 Acetylation
K310 Ubiquitination
Y312 Phosphorylation
S325 Phosphorylation
S338 Phosphorylation
S339 Phosphorylation
Y344 Phosphorylation
Y345 Phosphorylation
K382 Ubiquitination
K407 Ubiquitination
K455 Ubiquitination
K513 Ubiquitination
S520 Phosphorylation
T522 Phosphorylation
S523 Phosphorylation

Research Backgrounds

Subcellular Location:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

According to ubiquitously expressed. According to expressed specifically in testis and ovary.

Subunit Structure:

Heterodimer with VANGL2. Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction (By similarity).

Family&Domains:

Belongs to the Vang family.

Research Fields

· Environmental Information Processing > Signal transduction > Wnt signaling pathway.   (View pathway)

References

1). Study of the mechanism by which Xiaoyan decoction combined with E7449 regulates tumorigenesis in lung adenocarcinoma. Journal of cellular and molecular medicine, 2024 (PubMed: 38898581) [IF=5.3]

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