TIE1 Antibody - #DF4582
Product: | TIE1 Antibody |
Catalog: | DF4582 |
Description: | Rabbit polyclonal antibody to TIE1 |
Application: | WB |
Reactivity: | Human, Mouse, Rat |
Prediction: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
Mol.Wt.: | 130 KD; 125kD(Calculated). |
Uniprot: | P35590 |
RRID: | AB_2836946 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4582, RRID:AB_2836946.
Fold/Unfold
JKT 14; JTK14; TIE; Tie1; TIE1_HUMAN; Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains; Tyrosine kinase with immunoglobulin-like and EGF-like domains 1; Tyrosine protein kinase receptor Tie 1; Tyrosine-protein kinase receptor Tie-1;
Immunogens
- P35590 TIE1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPPLLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P35590 As Substrate
Site | PTM Type | Enzyme | Source |
---|---|---|---|
T393 | Phosphorylation | Uniprot | |
S472 | Phosphorylation | Uniprot | |
S478 | Phosphorylation | Uniprot | |
T539 | Phosphorylation | Uniprot | |
T540 | Phosphorylation | Uniprot | |
S598 | Phosphorylation | Uniprot | |
S599 | Phosphorylation | Uniprot | |
T604 | Phosphorylation | Uniprot | |
T608 | Phosphorylation | Uniprot | |
T663 | Phosphorylation | Uniprot | |
Y912 | Phosphorylation | Uniprot | |
Y1007 | Phosphorylation | Uniprot | |
T1011 | Phosphorylation | Uniprot | |
Y1027 | Phosphorylation | Uniprot | |
Y1030 | Phosphorylation | Uniprot | |
T1031 | Phosphorylation | Uniprot | |
T1032 | Phosphorylation | Uniprot | |
Y1083 | Phosphorylation | Uniprot |
Research Backgrounds
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
Cell membrane>Single-pass type I membrane protein.
Specifically expressed in developing vascular endothelial cells.
Heterodimer with TEK/TIE2.
Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
References
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