Product: TMBIM1 Antibody
Catalog: DF4580
Description: Rabbit polyclonal antibody to TMBIM1
Application: WB IF/ICC
Reactivity: Human, Mouse, Rat
Prediction: Pig, Bovine, Horse, Rabbit, Dog, Xenopus
Mol.Wt.: 35 KD; 35kD(Calculated).
Uniprot: Q969X1
RRID: AB_2836944

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 100ul $280 In stock
 200ul $350 In stock

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Product Info

Source:
Rabbit
Application:
WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse,Rat
Prediction:
Pig(100%), Bovine(100%), Horse(88%), Rabbit(100%), Dog(100%), Xenopus(100%)
Clonality:
Polyclonal
Specificity:
TMBIM1 Antibody detects endogenous levels of total TMBIM1.
RRID:
AB_2836944
Cite Format: Affinity Biosciences Cat# DF4580, RRID:AB_2836944.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

LFG3; MST100; MSTP100; PP1201; Protein lifeguard 3; Protein RECS1 homolog; RECS1; TMBI1_HUMAN; Tmbim1; Transmembrane BAX inhibitor motif containing 1; Transmembrane BAX inhibitor motif-containing protein 1;

Immunogens

Immunogen:
Uniprot:
Gene(ID):
Sequence:
MSNPSAPPPYEDRNPLYPGPPPPGGYGQPSVLPGGYPAYPGYPQPGYGHPAGYPQPMPPTHPMPMNYGPGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVTGIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Bovine
100
Dog
100
Xenopus
100
Rabbit
100
Horse
88
Sheep
75
Chicken
75
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q969X1 As Substrate

Site PTM Type Enzyme
S2 Phosphorylation
Y67 Phosphorylation
Y73 Phosphorylation
S81 Phosphorylation
S83 Phosphorylation
S127 Phosphorylation

Research Backgrounds

Function:

Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.

Subcellular Location:

Membrane>Multi-pass membrane protein. Lysosome membrane. Endosome membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Family&Domains:

Belongs to the BI1 family. LFG subfamily.

References

1). miR‐485's anti‐drug resistant epilepsy effects by regulating SV2A/PSD‐95 and targeting ABCC1 and neuronal signaling‐transduction proteins in hippocampus of rats. Brain and Behavior, 2021 (PubMed: 34291586) [IF=3.1]

Application: WB    Species: Rat    Sample: hippocampus tissue

FIGURE 6 Theexpressionofneuronalsignaling-transduction proteinsinhippocampusofDREratsat9weeksafterSE.(a)Western blottingbands;(b)barographsofexpressionlevels.*p<.05versusthe

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For Research Use Only.
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