THBD Antibody - #DF4565
| Product: | THBD Antibody |
| Catalog: | DF4565 |
| Description: | Rabbit polyclonal antibody to THBD |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse, Rat |
| Prediction: | Bovine, Sheep, Rabbit, Dog |
| Mol.Wt.: | 100kd; 60kD(Calculated). |
| Uniprot: | P07204 |
| RRID: | AB_2836916 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4565, RRID:AB_2836916.
Fold/Unfold
AHUS 6; AHUS6; BDCA 3; BDCA3; CD 141; CD141; CD141 antigen; Fetomodulin; Thbd; THPH12; THRM; Thrombomodulin; TM; TRBM_HUMAN;
Immunogens
- P07204 TRBM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLMTVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL
Predictions
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P07204 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S492 | O-Glycosylation | Uniprot | |
| K553 | Ubiquitination | Uniprot | |
| K559 | Ubiquitination | Uniprot |
Research Backgrounds
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
N-glycosylated.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Membrane>Single-pass type I membrane protein.
Endothelial cells are unique in synthesizing thrombomodulin.
Interacts with ITGAL, ITGAM and ITGB2.
Extracellular region (481-515) contains a binding side for alpha-L/beta-2 and alpha-M/beta-2 integrin.
Research Fields
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
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