SFRS7 Antibody - #DF4544

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Product: SFRS7 Antibody
Catalog: DF4544
Description: Rabbit polyclonal antibody to SFRS7
Application: WB IHC IF/ICC
Reactivity: Human, Mouse
Prediction: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
Mol.Wt.: 35 KD; 27kD(Calculated).
Uniprot: Q16629
RRID: AB_2836895

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 100ul $280 In stock
 200ul $350 In stock

Lead Time: Same day delivery

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Related Downloads
MS Report
HPLC Report
MSDS
Data Sheet
COA
Protocols
WB Handbook
IHC Protocol
IF/ICC Protocol

Product Info

Source:
Rabbit
Application:
IHC 1:50-1:200, WB 1:500-1:1000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

Reactivity:
Human,Mouse
Prediction:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(94%), Xenopus(94%)
Clonality:
Polyclonal
Specificity:
SFRS7 Antibody detects endogenous levels of total SFRS7.
RRID:
AB_2836895
Cite Format: Affinity Biosciences Cat# DF4544, RRID:AB_2836895.
Conjugate:
Unconjugated.
Purification:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
Alias:

Fold/Unfold

9G8; AAG3; arginine/serine-rich 7; HSSG1; RBM37; Serine/arginine-rich splicing factor 7; Splicing factor 9G8; Splicing factor; Splicing factor, arginine/serine rich 7; SRSF7; SRSF7_HUMAN; ZCCHC20; ZCRB2;

Immunogens

Immunogen:
Uniprot:

Q16629(SRSF7_HUMAN) >>Visit HPA database.

Gene(ID):
SRSF7(6432)
Expression:
Q16629 SRSF7_HUMAN:

Brain, liver, kidney and lung.

Sequence:
MSRYGRYGGETKVYVGNLGTGAGKGELERAFSYYGPLRTVWIARNPPGFAFVEFEDPRDAEDAVRGLDGKVICGSRVRVELSTGMPRRSRFDRPPARRPFDPNDRCYECGEKGHYAYDCHRYSRRRRSRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRRSRSASLRRSRSGSIKGSRYFQSPSRSRSRSRSISRPRSSRSKSRSPSPKRSRSPSGSPRRSASPERMD

Predictions

Predictions:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
94
Chicken
94
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q16629 As Substrate

Site PTM Type Enzyme
Y4 Phosphorylation
Y7 Phosphorylation
K12 Sumoylation
K12 Ubiquitination
Y14 Phosphorylation
T20 Phosphorylation
K24 Acetylation
K24 Sumoylation
K24 Ubiquitination
S32 Phosphorylation
Y33 Phosphorylation
Y34 Phosphorylation
K70 Acetylation
K70 Ubiquitination
C73 S-Nitrosylation
R98 Methylation
R105 Methylation
Y107 Phosphorylation
K112 Acetylation
K112 Ubiquitination
Y117 Phosphorylation
S123 Phosphorylation
S155 Phosphorylation
S157 Phosphorylation
S159 Phosphorylation
S163 Phosphorylation
S165 Phosphorylation
S167 Phosphorylation
S171 Phosphorylation
S173 Phosphorylation
S175 Phosphorylation
S179 Phosphorylation
S181 Phosphorylation
S183 Phosphorylation
K185 Acetylation
S187 Phosphorylation
Y189 Phosphorylation
S192 Phosphorylation
S194 Phosphorylation
S196 Phosphorylation
S198 Phosphorylation
S200 Phosphorylation
S202 Phosphorylation
S204 Phosphorylation
S213 Phosphorylation
S215 Phosphorylation
S217 Phosphorylation
S221 Phosphorylation
S223 Phosphorylation
S225 Phosphorylation
S227 Phosphorylation
S231 Phosphorylation
S233 Phosphorylation
R236 Methylation

Research Backgrounds

Function:

Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.

PTMs:

Extensively phosphorylated on serine residues in the RS domain.

Subcellular Location:

Nucleus. Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
Tissue Specificity:

Brain, liver, kidney and lung.

Subunit Structure:

Found in large molecular weight complexes containing CCNL1 and the p110 isoforms of either CDC2L1 or CDC2L2. Interacts with CCNL2 and CPSF6. Interacts with NXF1.

Family&Domains:

Belongs to the splicing factor SR family.

Research Fields

· Genetic Information Processing > Transcription > Spliceosome.

· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.

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