SLC24A1 Antibody - #DF4523
| Product: | SLC24A1 Antibody |
| Catalog: | DF4523 |
| Description: | Rabbit polyclonal antibody to SLC24A1 |
| Application: | WB IF/ICC |
| Reactivity: | Human, Mouse |
| Mol.Wt.: | 121 KD; 121kD(Calculated). |
| Uniprot: | O60721 |
| RRID: | AB_2836874 |
Related Downloads
Protocols
Product Info
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
Cite Format: Affinity Biosciences Cat# DF4523, RRID:AB_2836874.
Fold/Unfold
CSNB1D; HsT17412; KIAA0702; Na(+)/K(+)/Ca(2+) exchange protein 1; Na(+)/K(+)/Ca(2+)-exchange protein 1; NCKX; NCKX1; NCKX1_HUMAN; Retinal rod Na Ca+K exchanger; Retinal rod Na+/Ca+/K+ exchanger; Retinal rod Na-Ca+K exchanger; RODX; Slc24a1; Sodium/potassium/calcium exchanger 1; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 1; Solute carrier family 24 member 1;
Immunogens
Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.
- O60721 NCKX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGKLIRMGPQERWLLRTKRLHWSRLLFLLGMLIIGSTYQHLRRPRGLSSLWAAVSSHQPIKLASRDLSSEEMMMMSSSPSKPSSEMGGKMLVPQASVGSDEATLSMTVENIPSMPKRTAKMIPTTTKNNYSPTAAGTERRKEDTPTSSRTLTYYTSTSSRQIVKKYTPTPRGEMKSYSPTQVREKVKYTPSPRGRRVGTYVPSTFMTMETSHAITPRTTVKDSDITATYKILETNSLKRIMEETTPTTLKGMFDSTPTFLTHEVEANVLTSPRSVMEKNNLFPPRRVESNSSAHPWGLVGKSNPKTPQGTVLLHTPATSEGQVTISTMTGSSPAETKAFTAAWSLRNPSPRTSVSAIKTAPAIVWRLAKKPSTAPSTSTTPTVRAKLTMQVHHCVVVKPTPAMLTTPSPSLTTALLPEELSPSPSVLPPSLPDLHPKGEYPPDLFSVEERRQGWVVLHVFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCSLFSREILNLTWWPLFRDVSFYILDLIMLILFFLDSLIAWWESLLLLLAYAFYVFTMKWNKHIEVWVKEQLSRRPVAKVMALEDLSKPGDGAIAVDELQDNKKLKLPSLLTRGSSSTSLHNSTIRSTIYQLMLHSLDPLREVRLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPGGQEDVAEAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGDNEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNEEPLSLDWPETRQKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVFTFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV
PTMs - O60721 As Substrate
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K120 | Acetylation | Uniprot | |
| T144 | Phosphorylation | Uniprot | |
| T152 | Phosphorylation | Uniprot | |
| Y153 | Phosphorylation | Uniprot | |
| S156 | Phosphorylation | Uniprot | |
| S158 | Phosphorylation | Uniprot | |
| S159 | Phosphorylation | Uniprot | |
| Y166 | Phosphorylation | Uniprot | |
| T167 | Phosphorylation | Uniprot | |
| T169 | Phosphorylation | Uniprot | |
| T189 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| S629 | Phosphorylation | Uniprot | |
| S651 | Phosphorylation | Uniprot | |
| T654 | Phosphorylation | Uniprot | |
| S658 | Phosphorylation | Uniprot | |
| T724 | Phosphorylation | Uniprot | |
| T726 | Phosphorylation | Uniprot | |
| T769 | Phosphorylation | Uniprot |
Research Backgrounds
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration.
Membrane>Multi-pass membrane protein.
Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
Research Fields
· Organismal Systems > Sensory system > Phototransduction.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.